ArticleJournal of molecular histology2013
Up-regulation of Smurf1 after spinal cord injury in adult rats.
Article in Journal of molecular histology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR-340-5p/Smurf1 axis.Immunity, inflammation and disease · 2023Article
- Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin.The Journal of biological chemistry · 2022Article
- microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury.Journal of cellular and molecular medicine · 2021Article
- The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation.Cellular and molecular neurobiology · 2018Article
- Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.International journal of clinical and experimental pathology · 2015Article
- Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.Journal of molecular histology · 2014Article
- Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.Cellular and molecular life sciences : CMLS · 2014Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smad ubiquitination regulatory factor 1 (Smurf1) is one of members of the Hect family of proteins, which also includes the ubiquitin E3-type ligases Nedd3 and E6-AP. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated Smads to trigger their ubiquitination and degradation. Recently, a report indicates that Smurf1 can inhibit apoptosis by regulating p53 negatively, which depends on the effect of Smurf1 stabilizing the MDM2-MDMX complex. However, the roles of Smurf1 in central nervous system injury remain to be unknown. In our study, we finished acute spinal cord injury (SCI) in adult rats to research the protein expression and cellular localization of Smurf1 in spinal cord. Western blot analysis showed that Smurf1 was low expressed in normal spinal cord. It was increased at 6 h after SCI, peaked at 1 day, remained for 3 days, and then declined gradually during the following days. Immunohistochemistry further confirmed that Smurf1 immunoactivity was expressed at low levels in the gray matter and white matter in normal condition and increased after SCI. Double immunofluorescence staining showed that Smurf1 was co-expressed NeuN (neuronal marker), CNPase (oligodendroglial marker), and active caspase-3 at 1 day post-injury. Additionally, p53 and MDM2 levels were up-regulated after SCI consistently. All these findings suggest that Smurf1 might be involved in the pathophysiology of spinal cord after SCI.
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