ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Dopamine triggers heterosynaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Cortical and Thalamic Interaction with Amygdala-to-Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- High Content Analysis Across Signaling Modulation Treatments for Subcellular Target Identification Reveals Heterogeneity in Cellular Response.Frontiers in cell and developmental biology · 2020Article
- Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens.Scientific reports · 2019Article
- PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Alterations in Striatal Circuits Underlying Addiction-Like Behaviors.Molecules and cells · 2017Review
- In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons.Genes, brain, and behavior · 2016Article
- Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice.Molecular imaging and biology · 2015Article
- Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Stress and VTA synapses: implications for addiction and depression.The European journal of neuroscience · 2014Review
- Hemispheric differences in the mesostriatal dopaminergic system.Frontiers in systems neuroscience · 2014Review
- Neuromodulatory adaptive combination of correlation-based learning in cerebellum and reward-based learning in basal ganglia for goal-directed behavior control.Frontiers in neural circuits · 2014Article
- Article
- Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
As a classic neuromodulator, dopamine has long been thought to modulate, rather than trigger, synaptic plasticity. In contrast, our present results demonstrate that within the parallel projections of dopaminergic and GABAergic terminals from the ventral tegmental area to the nucleus accumbens core (NAcCo), action-potential-activated release of dopamine heterosynaptically triggers LTD at GABAergic synapses, which is likely mediated by activating presynaptically located dopamine D1 class receptors and expressed by inhibiting presynaptic release of GABA. Moreover, this dopamine-mediated heterosynaptic LTD is abolished after withdrawal from cocaine exposure. These results suggest that action-potential-dependent dopamine release triggers very different cellular consequences from those induced by volume release or pharmacological manipulation. Activation of the ventral tegmental area to NAcCo projections is essential for emotional and motivational responses. This dopamine-mediated LTD allows a flexible output of NAcCo neurons, whereas disruption of this LTD may contribute to the rigid emotional and motivational state observed in addicts during cocaine withdrawal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.