Evidence map›Paper›PMID 23595539›Full record

ReviewChemical Society reviews2013

Glycopolymer probes of signal transduction.

Laura L Kiessling, Joseph C Grim

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 326 citations in OpenAlex.

  1. Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2-Deoxyglucose.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Monosaccharide Binding to Synthetic Carbohydrate Receptor Microarrays.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
  3. Review
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  12. Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura L KiesslingDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, WI 53706, USA. kiessling@chem.wisc.edu
Joseph C Grim
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Synthetic Ligands for Modulating Immune Cell ResponsesR01AI055258 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 2003 to 2024
$7.8M
PROBES OF CARBOHYDRATE FUNCTIONR01GM049975 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 1999 to 2016
$5.2M
MULTIVALENT PROTEIN CARBOHYDRATE INTERACTIONSR01GM055984 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 1997 to 2014
$3.9M
The Chemistry and Biology of Galactofuranose ResiduesR01AI063596 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 2005 to 2014
$3.0M
NCI NIH HHS P30 CA014520NIAID NIH HHS R01 AI055258NIAID NIH HHS R01 AI063596NIGMS NIH HHS R01 GM049975NIGMS NIH HHS R01 GM055984
6 · The paper itself

Abstract

Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end, glycopolymers (polymers bearing pendant carbohydrates) have emerged as valuable glycan analogs. Because glycopolymers can readily be synthesized, their overall shape can be varied, and they can be altered systematically to dissect the structural features that underpin their activities. This review provides examples in which glycopolymers have been used to effect carbohydrate-mediated signal transduction. Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction.

Indexed as

Biomimetic MaterialsHumansMolecular ProbesMucinsPolymersPolysaccharidesReceptors, Cell SurfaceSignal TransductionMolecular ProbesMucinsPolymersPolysaccharidesReceptors, Cell Surface

Identifiers

PMID23595539
PMCPMC3808984
OpenAlexW2077058827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.