ArticleClinical and vaccine immunology : CVI2013
Reduced frequency of a CD14+ CD16+ monocyte subset with high Toll-like receptor 4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns.
Article in Clinical and vaccine immunology : CVI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Intracellular concentration of ADA2 is a marker for monocyte differentiation and activation.Frontiers of medicine · 2025Article
- Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14International journal of molecular sciences · 2023Article
- The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages.Frontiers in immunology · 2021Article
- Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model.Scientific reports · 2020Article
- Article
- Changes in monocyte subsets are associated with clinical outcomes in severe malarial anaemia and cerebral malaria.Scientific reports · 2019Article
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.Cell reports · 2019Article
- Infant Immune Response to Respiratory Viral Infections.Immunology and allergy clinics of North America · 2019Review
- Sex-differences in LPS-induced neonatal lung injury.Scientific reports · 2019Article
- Unique aspects of the perinatal immune system.Nature reviews. Immunology · 2017Review
- Reduced internalization of TNF-ɑ/TNFR1 down-regulates caspase dependent phagocytosis induced cell death (PICD) in neonatal monocytes.PloS one · 2017Article
- Comparison of Human Neonatal and Adult Blood Leukocyte Subset Composition Phenotypes.PloS one · 2016Article
- CD14 expression is increased on monocytes in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis and correlates with the expression of ANCA autoantigens.Clinical and experimental immunology · 2015Article
- TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.PloS one · 2015Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia.Journal of neuroinflammation · 2014Article
- Ontogeny of myeloid cells.Frontiers in immunology · 2014Review
- Immunity to RSV in Early-Life.Frontiers in immunology · 2014Review
- Elevated soluble CD163 plasma levels are associated with disease severity in patients with hemorrhagic fever with renal syndrome.PloS one · 2014Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The human innate immune response to pathogens is not fully effective and mature until well into childhood, as exemplified by various responses to Toll-like receptor (TLR) agonists in newborns compared to adults. To better understand the mechanistic basis for this age-related difference in innate immunity, we compared tumor necrosis factor alpha (TNF-α) production by monocytes from cord blood (CB) and adult blood (AB) in response to LAM (lipoarabinomannan from Mycobacterium tuberculosis, a TLR2 ligand) and LPS (lipopolysaccharide from Escherichia coli, a TLR4 ligand). LPS or LAM-induced TNF-α production was 5 to 18 times higher in AB than in CB monocytes, whereas interleukin-1α (IL-1α) stimulated similar levels of TNF-α in both groups, suggesting that decreased responses to LPS or LAM in CB are unlikely to be due to differences in the MyD88-dependent signaling pathway. This impaired signaling was attributable, in part, to lower functional TLR4 expression, especially on CD14(+) CD16(+) monocytes, which are the primary cell subset for LPS-induced TNF-α production. Importantly, the frequency of CD14(+) CD16(+) monocytes in CB was 2.5-fold lower than in AB (P < 0.01). CB from Kenyan newborns sensitized to parasite antigens in utero had more CD14(+) CD16(+) monocytes (P = 0.02) and produced higher levels of TNF-α in response to LPS (P = 0.004) than CB from unsensitized Kenyan or North American newborns. Thus, a reduced CD14(+) CD16(+) activated/differentiated monocyte subset and a correspondingly lower level of functional TLR4 on monocytes contributes to the relatively low TNF-α response to LPS observed in immunologically naive newborns compared to the response in adults.
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