SynthesisIntensive care medicine2013
Prognostic value of troponins in sepsis: a meta-analysis.
Synthesis in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 4 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis.Critical care (London, England) · 2025Pooled it
- Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta-analysis.Immunity, inflammation and disease · 2023Pooled it
- Elevated Cardiac Troponin in Clinical Scenarios Beyond Obstructive Coronary Artery Disease.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- A machine learning model for in-hospital mortality prediction in patients with sepsis-related myocardial injury.PLOS digital health · 2026Article
- Septic cardiomyopathy: Fact or fiction?American heart journal plus : cardiology research and practice · 2026Review
- Identification and validation of MYC as an autophagy-related gene for diagnosis and immune infiltration in sepsis-induced myocardial dysfunction.Journal of cardiothoracic surgery · 2026Article
- Neonatal sepsis and cardiovascular dysfunction II: assessment.Pediatric research · 2026Review
- Comparative prognostic value of high-sensitivity cardiac troponin T and NT-proBNP for 30-day mortality in non-cardiac critically ill patients.Scientific reports · 2026Article
- QT interval prolongation and mortality in sepsis: a retrospective cohort study from the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- The Role of Pyroptosis in Exacerbating Sepsis-Induced Myocardial Injury: Mechanisms and Implications.Journal of inflammation research · 2026Review
- Cardiac Troponin I as a Prognostic Indicator of Mortality in Patients With Sepsis and Organ Dysfunction.Cureus · 2026Article
- A Diagnostic Dilemma: Urosepsis Mimicking ST-elevation Myocardial Infarction: A Case Report and Review of the Literature.Heart views : the official journal of the Gulf Heart Association · 2026Article
- Early time-weighted average PEEP and mortality in sepsis-associated myocardial injury requiring invasive mechanical ventilation: a retrospective cohort study with external validation.Frontiers in cellular and infection microbiology · 2026Article
- Troponin I as a prognostic marker for outcomes in septic patients admitted to the ICU: Evidence from a government medical college of Madhya Pradesh, India.Bioinformation · 2026Article
- Multi-omics analysis identifies NFIL3 as a hypoxia-associated immune regulator in septic cardiomyopathy.Frontiers in immunology · 2026Article
- Elevated Cardiac Troponin in Non-Cardiac Conditions Unrelated to Acute Myocardial Infarction.International journal of molecular sciences · 2025Review
- Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study.Critical care (London, England) · 2025Observational
- 5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy.Scientific reports · 2025Article
- Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study.European journal of medical research · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe role of biomarkers such as troponin in risk stratification of sepsis is still debated. The aim of this meta-analysis is to assess the relation between troponin elevation in sepsis and mortality.
methodsAll observational studies from Embase, Medline and those manually searched up to September 2010 were included. Studies identified were those which reported on patients with a diagnosis of sepsis and if a 2 × 2 table could be constructed based on troponins and death. We pooled the relative risk (RR) and odds-ratio (OR) using the inverse variance method in studies that conducted univariate and multivariable (adjusted) analysis. MAIN
resultsThirteen studies encompassing 1,227 patients were included. The prevalence of elevated troponin was 61 % ([95 %] CI 58-64 %). Elevated troponin was significantly associated with all-cause mortality (RR 1.91; CI 1.63-2.24), with homogeneity across studies. In adjusted analysis (four studies comprising 791 patients) according to prognostic scores, elevated troponin was associated with an increased risk of death (OR 1.92; CI 1.35-2.74). The area under the ROC curve was 0.68 (CI 0.63-0.71). Pooled sensitivity and specificity were 77 % (CI 61-88) and 47 % (CI 30-64) with heterogeneity across studies. It corresponded to positive and negative likelihood ratios of 1.50 (95 % CI: 1.20-1.90) and 0.49 (CI 0.38-0.64), respectively.
conclusionsElevated troponin identifies a subset of patients with sepsis at higher risk of death. Further studies are needed to define the precise role of troponins and their optimal cut-offs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.