Trial reportAnnals of neurology2013
Elevated temperature and 6- to 7-year outcome of neonatal encephalopathy.
Trial report in Annals of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Time to Reaching Target Cooling Temperature and 2-year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.The Journal of pediatrics · 2024Trial
- Comparison of rectal and axillary temperature measurements in preterm newborns.Archives of disease in childhood. Fetal and neonatal edition · 2021Trial
- Trial
- Trial
- Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.The New England journal of medicine · 2017Trial
- Trial
- Consensus definition and diagnostic criteria for neonatal encephalopathy-study protocol for a real-time modified delphi study.Pediatric research · 2025Article
- Association between combined use of epidural analgesia and oxytocin administration during labor and offspring outcomes: a narrative review and proposal.Nagoya journal of medical science · 2024Review
- Hypothermia for Hypoxic-ischemic Encephalopathy: Second-generation Trials to Address Gaps in Knowledge.Clinics in perinatology · 2024Review
- A bibliometric study on clinical research in neonatal encephalopathy.Frontiers in pediatrics · 2024Review
- Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.Seminars in perinatology · 2022Review
- The critical importance of follow-up to school age: Contributions of the NICHD Neonatal Research Network.Seminars in perinatology · 2022Article
- Body temperature, heart rate and long-term outcome of cooled infants: an observational study.Pediatric research · 2022Observational
- Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Therapeutic hypothermia for neonatal encephalopathy with sepsis: a retrospective cohort study.BMJ paediatrics open · 2022Article
- Effects of Juvenile or Adolescent Working Memory Experience and Inter-Alpha Inhibitor Protein Treatment after Neonatal Hypoxia-Ischemia.Brain sciences · 2020Article
- Body temperatures of very low birth weight infants on admission to a neonatal intensive care unit.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Article
- Therapeutic Hypothermia: How Can We Optimize This Therapy to Further Improve Outcomes?Clinics in perinatology · 2018Review
- Rectal temperature in the first five hours after hypoxia-ischemia critically affects neuropathological outcomes in neonatal rats.Pediatric research · 2018Article
- Relationship between temperature variability and brain injury on magnetic resonance imaging in cooled newborn infants after perinatal asphyxia.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveA study was undertaken to determine whether higher temperature after hypoxia-ischemia is associated with death or intelligence quotient (IQ)<70 at 6 to 7 years among infants treated with intensive care without hypothermia.
methodsControl infants (noncooled, n=106) of the National Institute of Child Health and Human Development Neonatal Research Network hypothermia trial had serial esophageal and skin temperatures over 72 hours. Each infant's temperature was ranked to derive an average of the upper and lower quartile, and median of each site. Temperatures were used in logistic regressions to determine adjusted associations with death or IQ<70 at 6 to 7 years. Secondary outcomes were death, IQ<70, and moderate/severe cerebral palsy (CP). IQ and motor function were assessed with Wechsler Scales for Children and Gross Motor Function Classification System. Results are odds ratio (OR; per degree Celsius increment within the quartile or median) and 95% confidence interval (CI).
resultsPrimary outcome was available for 89 infants. At 6 to 7 years, death or IQ<70 occurred in 54 infants (37 deaths, 17 survivors with IQ<70) and moderate/severe CP in 15 infants. Death or IQ<70 was associated with the upper quartile average of esophageal (OR=7.3, 95% CI=2.0-26.3) and skin temperature (OR=3.5, 95% CI=1.2-10.4). CP was associated with the upper quartile average of esophageal (OR=12.5, 95% CI=1.02-155) and skin temperature (OR=10.3, 95% CI=1.3-80.2).
interpretationAmong noncooled infants of a randomized trial, elevated temperatures during the first postnatal days are associated with increased odds of a worse outcome at 6 to 7 years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.