ArticlePlant molecular biology2013
Plastid division control: the PDV proteins regulate DRP5B dynamin activity.
Article in Plant molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Binary division of plastids involves endoplasmic reticulum mediation.Journal of experimental botany · 2025Article
- Integrated genomic and transcriptomic analysis reveals the mechanisms underlying leaf variegation in 'Gonggan' mandarin.BMC plant biology · 2025Article
- Auxin promotes chloroplast division by increasing the expression of chloroplast division genes.Plant cell reports · 2024Article
- Structural and functional insights into the chloroplast division site regulators PARC6 and PDV1 in the intermembrane space.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mutation of SlARC6 leads to tissue-specific defects in chloroplast development in tomato.Horticulture research · 2021Article
- PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.Plant physiology · 2020Article
- Article
- The Molecular Machinery of Chloroplast Division.Plant physiology · 2018Review
- Dynamin-Like Proteins Are Potentially Involved in Membrane Dynamics within Chloroplasts and Cyanobacteria.Frontiers in plant science · 2018Article
- Article
- Variations in chloroplast movement and chlorophyll fluorescence among chloroplast division mutants under light stress.Journal of experimental botany · 2017Article
- PDV2 has a dosage effect on chloroplast division in Arabidopsis.Plant cell reports · 2017Article
- Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.Protein science : a publication of the Protein Society · 2016Article
- Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly.Plant physiology · 2016Article
- Phosphatidylinositol 4-phosphate negatively regulates chloroplast division in Arabidopsis.The Plant cell · 2015Article
- The puzzle of chloroplast vesicle transport - involvement of GTPases.Frontiers in plant science · 2014Review
- FtsZ-less prokaryotic cell division as well as FtsZ- and dynamin-less chloroplast and non-photosynthetic plastid division.Frontiers in plant science · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloroplast division represents a fundamental but complex biological process involving remnants of the ancestral bacterial division machinery and proteins of eukaryotic origin. Moreover, the chloroplast division machinery is divided into stromal and cytosolic sub machineries, which coordinate and control their activities to ensure appropriate division initiation and progression. Dynamin related protein 5B (DRP5B) and plastid division protein 1 and 2 (PDV1 and PDV2) are all plant-derived proteins and represent components of the cytosolic division machinery, where DRP5B is thought to exert constrictional force during division. However, the direct relationship between PDV1, PDV2 and DRP5B, and moreover how DRP5B is regulated during plastid constriction remains unclear. In this study we show that PDV1 and PDV2 can interact with themselves and with each other through their cytosolic domains. We demonstrate that DRP5B interacts with itself and with the cytosolic region of PDV1 and that the two functional isoforms of DRP5B have highly overlapping functions. We further show that DRP5B harbors GTPase activity and moreover that PDV1 and PDV2 inhibits DRP5B-mediated GTP hydrolysis in a ratio dependent manner. Our data suggest that the PDV proteins contribute to the regulation of DRP5B activity thereby enforcing control over the division process during early constriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.