SynthesisJournal of cancer research and clinical oncology2013
Prognostic significance of several biomarkers in epithelial ovarian cancer: a meta-analysis of published studies.
Synthesis in Journal of cancer research and clinical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer.International journal of clinical and experimental pathology · 2015Pooled it
- Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC.Oncotarget · 2016Trial
- HPV-positive cancers at uncommon sites: a narrative review.Oncology reviews · 2026Review
- Effect of Ionizing Radiation on the Transcript Variants Expression of p21 Gene.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Dacomitinib improves chemosensitivity of cisplatin-resistant human ovarian cancer cells.Oncology letters · 2021Article
- Glutathione S-Transferases in Cancer.Antioxidants (Basel, Switzerland) · 2021Review
- Activating p53 function by targeting RLIP.Biochimica et biophysica acta. Reviews on cancer · 2021Review
- A Study of Prognostic Factors in Young Patients With Non-HPV Oral Cancer in Central Europe.Pathology oncology research : POR · 2021Article
- Article
- Distinct plasma lipids profiles of recurrent ovarian cancer by liquid chromatography-mass spectrometry.Oncotarget · 2017Article
- MicroRNA-298 inhibits malignant phenotypes of epithelial ovarian cancer by regulating the expression of EZH2.Oncology letters · 2016Article
- Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- High levels of EGFR expression in tumor stroma are associated with aggressive clinical features in epithelial ovarian cancer.OncoTargets and therapy · 2016Article
- Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells.Cancer medicine · 2015Article
- Molecular mechanism of increased sensitivity of cisplatin to ovarian cancer by inhibition of microRNA-23a expression.International journal of clinical and experimental medicine · 2015Article
- Expression of KAP1 in epithelial ovarian cancer and its correlation with drug-resistance.International journal of clinical and experimental medicine · 2015Article
- Optimized Prediction of Extreme Treatment Outcomes in Ovarian Cancer.Cancer informatics · 2015Article
- Cell-cycle protein expression in a population-based study of ovarian and endometrial cancers.Frontiers in oncology · 2015Article
- High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer.International journal of molecular sciences · 2014Article
- MicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAbnormal expression of several biomarkers might predict disease prognosis and response to chemotherapy in patients with epithelial ovarian cancer (EOC). However, the published data are inconsistent.
methodsEligible studies that investigated the association between survival or response to platinum-based chemotherapy in EOC and the expression status of Bcl-2, EGFR, GST, LRP, p16, p21, P-gp and TNF-α were identified by an electronic search of PubMed and Embase. The measures of interest were hazard ratio (HR) for survival or risk ratio for chemotherapy response. A meta-analysis was performed using the fixed-effect or random-effect models.
resultsThe number of eligible studies analyzed was 27 for Bcl-2, 22 for EGFR, 29 for GST, 12 for LRP, 16 for p16, 22 for p21, 27 for P-gp and three for TNF-α. A meta-analysis showed that high EGFR and P-gp expression was associated with poor overall survival (OS) (pooled adjusted HR = 1.826 and HR = 1.822). Only high GST expression was associated with improved OS (HR = 0.780). Furthermore, high p16 and P-gp expression was associated with poor progression-free survival (PFS) (HR = 1.550 and HR = 2.136). High GST expression was associated with improved PFS (HR = 0.689). Among these factors, only LRP, P-gp and TNF-α were associated with response to platinum-based chemotherapy.
conclusionsThe markers we analyzed are unlikely to be useful as predictors of prognosis and response to platinum-based chemotherapy in EOC patients in clinical practice.
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