ArticleGenes and immunity
Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.
Article in Genes and immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- B cell mechanisms underlie IgG glycan alterations in obesity.Glycobiology · 2026Article
- Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients.Genes and immunity · 2026Article
- Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis.Journal of neuroinflammation · 2024Article
- VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- What Kept Back on the Mirror of COVID-19-Related Acute Transverse Myelitis? A Genetic Background!Iranian journal of child neurology · 2023Article
- Clonal expansion and markers of directed mutation of IGHV4-34 B cells in plasmablasts during Kawasaki disease.Molecular immunology · 2022Article
- Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients.JCI insight · 2017Article
- Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment.Journal of neuroinflammation · 2017Article
- B-cell populations discriminate between pediatric- and adult-onset multiple sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.Acta neuropathologica · 2017Article
- B cells in MS and NMO: pathogenesis and therapy.Seminars in immunopathology · 2014Review
- The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.Frontiers in neurology · 2014Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Patients with the autoimmune disease multiple sclerosis (MS) typically present with the clinically isolated syndromes (CIS) transverse myelitis (TM) or optic neuritis (ON). B-cell disturbances have been well documented in patients with MS and CIS patients with ON, but not in CIS patients with TM, despite the fact that these patients have the worst clinical outcome of all CIS types. The goal of this study was to characterize the B-cell populations and immunoglobulin genetics in TM patients. We found a unique expansion of CD27(high) plasmablasts in both the cerebrospinal fluid and periphery of TM patients that is not present in ON patients. Additionally, plasmablasts from TM patients show evidence for positive selection with increased somatic hypermutation accumulation in VH4(+) B cells and receptor editing that is not observed in ON patients. These characteristics unique to TM patients may impact disease severity and progression.
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