Evidence map›Paper›PMID 23594712›Full record

ReviewCurrent opinion in lipidology2013

Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis.

Chuchun L Chang, Richard J Deckelbaum

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in lipidology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Chuchun L ChangInstitute of Human Nutrition and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Richard J Deckelbaum
Columbia University · US

Funding

POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
NUTRITIONT32DK007647 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anthony W Ferrante, Lori M Zeltser · 1990 to 2026
$7.4M
METABOLISM OF INTRAVENOUS LIPID EMULSIONSR01HL040404 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DECKELBAUM, RICHARD JOSEPH · 1988 to 2008
$2.9M
NHLBI NIH HHS HL40404NHLBI NIH HHS R01 HL040404NHLBI NIH HHS T32 HL007343NHLBI NIH HHS T32-HL007343NIDDK NIH HHS T32 DK007647NIDDK NIH HHS T32-DK007647
6 · The paper itself

Abstract

purpose of reviewThis article provides an updated review on mechanistic and molecular studies relating to the effects of n-3 fatty acids (FA) on inhibiting atherogenesis. RECENT

findingsThe effects of n-3 FA on modulating arterial lipoprotein lipase levels link to changes in lipid deposition in the arterial wall. Lipoprotein lipase expression in the arterial wall also relates to local macrophage-mediated inflammatory processes. Increasing evidence suggests that n-3 FA ameliorate inflammation, another key component in the development of atherosclerosis, including decreases in proinflammatory cytokine production. n-3 FA inhibit atherogenic signaling pathways and modulate the phenotypes of inflammatory leukocytes and their recruitment in the arterial wall. SUMMARY: New mechanistic insights into the antiatherogenic action of n-3 FA have emerged. These studies may contribute to future therapeutic advances in preventing mortality and morbidity associated with atherosclerosis.

Indexed as

AnimalsAnti-Inflammatory AgentsAtherosclerosisCardiotonic AgentsDietFatty Acids, Omega-3HumansLipid MetabolismLipoprotein LipasePlaque, AtheroscleroticAnti-Inflammatory AgentsCardiotonic AgentsFatty Acids, Omega-3Lipoprotein Lipase

Identifiers

PMID23594712
PMCPMC3918949
OpenAlexW2023318991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.