ArticleJournal of Alzheimer's disease : JAD2013
Visual motion event related potentials distinguish aging and Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment.Alzheimer's research & therapy · 2023Article
- Correlating Ocular Physiology and Visual Function with Mild Cognitive Loss in Senior Citizens in Taiwan.Journal of clinical medicine · 2022Article
- Aging Enhances Neural Activity in Auditory, Visual, and Somatosensory Cortices: The Common Cause Revisited.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Hyperexcitability in Aging Is Lost in Alzheimer's: What Is All the Excitement About?Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Associations between genetic variations and global motion perception.Experimental brain research · 2019Article
- The development of human visual cortex and clinical implications.Eye and brain · 2018Review
- Visual-motor embodiment of language: a few implications for the neuropsychological evaluation (in Alzheimer's disease).Frontiers in aging neuroscience · 2015Article
- Article
- Novel computer-based testing shows multi-domain cognitive dysfunction in patients with multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAging and Alzheimer's disease (AD) disrupt visuospatial processing and visual motion evoked potentials in a manner linked to navigational deficits.
objectiveOur goal is to determine if aging and AD have distinct effects on visual cortical motion processing for navigation.
methodsWe recorded visual motion event related potentials (ERPs) in young (YNC) and older normal controls (ONC), and early AD patients (EADs) who viewed rapidly changing optic flow stimuli that simulate naturalistic changes in heading direction, like those that occur when following a path of self-movement through the environment. After a random series of optic flow stimuli, a vertical motion stimulus was presented to verify sustained visual attention by demanding a rapid push-button response.
resultsOptic flow evokes robust ERPs that are delayed in aging and diminished in AD. The interspersed vertical motion stimuli yielded shorter N200 latencies in EADs, matching those in ONCs, but the EADs' N200 amplitudes remained small.
conclusionsAging and AD have distinct effects on visual sensory processing: aging delays evoked response, whereas AD diminishes responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.