Evidence map›Paper›PMID 23594123›Full record

ReviewExpert opinion on biological therapy2013

Can you vaccinate against substance abuse?

Thomas R Kosten, Coreen B Domingo

Abstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
  13. Psychostimulant addiction treatment.Neuropharmacology · 2014
    Review
  14. Review
  15. Review
  16. Vaccines against drugs of abuse: where are we now?Therapeutic advances in vaccines · 2014
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thomas R KostenMichael E DeBakey VA Medical Center, Baylor College of Medicine, Departments of Psychiatry, Neuroscience, Pharmacology & Immunology, 2002 Holcombe, VA Hospital Bldg 110, # 229 Houston, TX 77030, USA. Kosten@bcm.edu
Coreen B Domingo
Michael E. DeBakey VA Medical Center · US

Funding

Human methamphetamine vaccine: Translational Avante Garde AwardDP1DA033502 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI KOSTEN, THOMAS RICHARD · 2011 to 2015
$4.0M
Cocaine Vaccine for Methadone Maintained PatientsR01DA015477 · NIDA · YALE UNIVERSITY · PI ROUNSAVILLE, BRUCE · 2002 to 2006
$1.7M
NIDA NIH HHS DP1 DA033502NIDA NIH HHS R01 DA015477
6 · The paper itself

Abstract

Vaccines are being developed against substance abuse and most progress has been made with anti-cocaine, nicotine and opiate vaccines, but new ones are being developed for methamphetamine and may be in humans within 18 - 24 months. These haptenated vaccines share a common problem in that only about one-third of those vaccinated get a sufficiently robust antibody titer to enable them to effectively block drug use. This problem is being addressed with better carrier proteins and new adjuvants beyond alum. This review provides details about these developing vaccines that act through pharmacokinetic rather than pharmacodynamics blockade. Due to this pharmacokinetic mechanism of keeping abused drugs in the bloodstream and not allowing them entry into the brain or other organs, these vaccines have very few side effects compared to other blockers used in addictions treatment.

Indexed as

HumansSubstance-Related DisordersVaccinationVaccinesVaccines

Identifiers

PMID23594123
PMCPMC4154471
OpenAlexW2136901544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.