ArticleTissue engineering. Part A2013
Growth factors polymerized within fibrin hydrogel promote amylase production in parotid cells.
Article in Tissue engineering. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Hydrogels for Salivary Gland Tissue Engineering.Gels (Basel, Switzerland) · 2022Review
- Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022Review
- Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response.Oral diseases · 2021Article
- Building a Functional Salivary Gland for Cell-Based Therapy: More than Secretory Epithelial Acini.Tissue engineering. Part A · 2020Review
- Stress or injury induces cellular plasticity in salivary gland acinar cells.Cell and tissue research · 2020Article
- Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels.Acta biomaterialia · 2020Article
- Comparing human and mouse salivary glands: A practice guide for salivary researchers.Oral diseases · 2019Review
- Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering.Materials (Basel, Switzerland) · 2018Review
- Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line.PloS one · 2018Article
- L1 Peptide-Conjugated Fibrin Hydrogels Promote Salivary Gland Regeneration.Journal of dental research · 2017Article
- Three-dimensional cultures of mouse submandibular and parotid glands: a comparative study.Journal of tissue engineering and regenerative medicine · 2017Article
- Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics.Acta biomaterialia · 2017Article
- Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D.ACS biomaterials science & engineering · 2016Article
- Laminin-111 Peptides Conjugated to Fibrin Hydrogels Promote Formation of Lumen Containing Parotid Gland Cell Clusters.Biomacromolecules · 2016Article
- Biomaterials-based strategies for salivary gland tissue regeneration.Biomaterials science · 2016Article
- Neurons Self-Organize Around Salivary Epithelial Cells in Novel Co-Culture Model.Journal of stem cell and regenerative biology · 2016Article
- Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.Journal of dental research · 2015Article
- Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications.Tissue engineering. Part A · 2015Article
- 3D biofabrication strategies for tissue engineering and regenerative medicine.Annual review of biomedical engineering · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Salivary gland cell differentiation has been a recurring challenge for researchers as primary salivary cells show a loss of phenotype in culture. Particularly, parotid cells show a marked decrease in amylase expression, the loss of tight junction organization and proper cell function. Previously, Matrigel has been used successfully as an extracellular matrix; however, it is not practical for in vivo applications as it is tumorigenic. An alternative method could rely on the use of fibrin hydrogel (FH), which has been used extensively in biomedical engineering applications ranging from cardiovascular tissue engineering to wound-healing experiments. Although several groups have examined the effects of a three-dimensional (3D) environment on salivary cell cultures, little is known about the effects of FH on salivary cell cultures. The current study developed a 3D cell culture model to support parotid gland cell differentiation using a combination of FH and growth factor-reduced Matrigel (GFR-MG). Furthermore, FH polymerized with a combination of EGF and IGF-1 induced formation of 3D spheroids capable of amylase expression and an agonist-induced increase in the intracellular Ca(2+) concentration ([Ca(2+)]i) in salivary cells. These studies represent an initial step toward the construction of an artificial salivary gland to restore salivary gland dysfunction. This is necessary to reduce xerostomia in patients with compromised salivary function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.