ArticleNanotoxicology2014
The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide.
Article in Nanotoxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Eugenol attenuates TiOEnvironmental science and pollution research international · 2021Article
- TRP Channels as Cellular Targets of Particulate Matter.International journal of molecular sciences · 2021Review
- Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects.Toxicology and applied pharmacology · 2020Article
- Effects of Titanium Dioxide Nanoparticles Exposure on Human Health-a Review.Biological trace element research · 2020Review
- Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats.Particle and fibre toxicology · 2019Article
- Review
- Engineered nanoparticle exposure and cardiovascular effects: the role of a neuronal-regulated pathway.Inhalation toxicology · 2018Review
- The effects of inhaled multi-walled carbon nanotubes on blood pressure and cardiac function.Nanoscale research letters · 2018Article
- Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure.Nanotoxicology · 2018Article
- Metal Nanomaterial Toxicity Variations Within the Vascular System.Current environmental health reports · 2016Review
- The influence of inhaled multi-walled carbon nanotubes on the autonomic nervous system.Particle and fibre toxicology · 2016Article
- Xenobiotic pulmonary exposure and systemic cardiovascular response via neurological links.American journal of physiology. Heart and circulatory physiology · 2015Review
- Cardiovascular effects in rats after intratracheal instillation of metal welding particles.Inhalation toxicology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.