ArticlePLoS neglected tropical diseases2013
Onchocerciasis: the pre-control association between prevalence of palpable nodules and skin microfilariae.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control.International health · 2020Pooled it
- A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection.PLoS neglected tropical diseases · 2014Trial
- Article
- Comorbidities of onchocerciasis and non-communicable diseases, and determinants of continued transmission in Bafut Health District, Cameroon.BMC infectious diseases · 2026Article
- Onchocerca volvulus infection prevalence and intensity in Logo and Nyarambe Health Zones in Ituri, Democratic Republic of the Congo in 2010 and in 2021-2023: results of screening for clinical trials of moxidectin versus ivermectin.Parasites & vectors · 2026Article
- Modelling of onchocerciasis-associated skin and ocular disease and the impact of ivermectin treatment.Communications medicine · 2026Article
- HISTONCHO: A dataset of intervention histories for onchocerciasis control & elimination in sub-Saharan Africa.Scientific data · 2026Article
- Model-Based Geostatistical Mapping of the Prevalence of Onchocerca volvulus in Cameroon between 1971 and 2020.PLoS neglected tropical diseases · 2025Article
- Status of human onchocerciasis transmission in the Adamaoua region of Cameroon after 20 years of ivermectin mass distribution.PLoS neglected tropical diseases · 2025Article
- Concordance between Ov16 Rapid Diagnostic Test(RDT) and Ov16 Enzyme-Linked Immunosorbent Assay (ELISA) for the Diagnosis of Onchocerciasis in Areas of Contrasting Endemicity in Cameroon.Parasite epidemiology and control · 2023Article
- The prevalence of onchocerciasis in Africa and Yemen, 2000-2018: a geospatial analysis.BMC medicine · 2022Article
- Geospatial modeling of pre-intervention nodule prevalence of Onchocerca volvulus in Ethiopia as an aid to onchocerciasis elimination.PLoS neglected tropical diseases · 2022Article
- Multi-Class Skin Problem Classification Using Deep Generative Adversarial Network (DGAN).Computational intelligence and neuroscience · 2022Article
- Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.PLoS neglected tropical diseases · 2021Article
- The burden of skin disease and eye disease due to onchocerciasis in countries formerly under the African Programme for Onchocerciasis Control mandate for 1990, 2020, and 2030.PLoS neglected tropical diseases · 2021Article
- Scaling-Down Mass Ivermectin Treatment for Onchocerciasis Elimination: Modeling the Impact of the Geographical Unit for Decision Making.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- How does onchocerciasis-related skin and eye disease in Africa depend on cumulative exposure to infection and mass treatment?PLoS neglected tropical diseases · 2021Article
- Assessing Onchocerciasis Subcriticality from Pre-Intervention Cross-Sectional Surveys.The American journal of tropical medicine and hygiene · 2020Article
- Designing antifilarial drug trials using clinical trial simulators.Nature communications · 2020Article
- Projected Number of People With Onchocerciasis-Loiasis Coinfection in Africa, 1995 to 2025.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 6 countries.
Funding
Abstract
backgroundThe prospect of eliminating onchocerciasis from Africa by mass treatment with ivermectin has been rejuvenated following recent successes in foci in Mali, Nigeria and Senegal. Elimination prospects depend strongly on local transmission conditions and therefore on pre-control infection levels. Pre-control infection levels in Africa have been mapped largely by means of nodule palpation of adult males, a relatively crude method for detecting infection. We investigated how informative pre-control nodule prevalence data are for estimating the pre-control prevalence of microfilariae (mf) in the skin and discuss implications for assessing elimination prospects. METHODS AND
findingsWe analyzed published data on pre-control nodule prevalence in males aged ≥ 20 years and mf prevalence in the population aged ≥ 5 years from 148 African villages. A meta-analysis was performed by means of Bayesian hierarchical multivariate logistic regression, accounting for measurement error in mf and nodule prevalence, bioclimatic zones, and other geographical variation. There was a strong positive correlation between nodule prevalence in adult males and mf prevalence in the general population. In the forest-savanna mosaic area, the pattern in nodule and mf prevalence differed significantly from that in the savanna or forest areas. SIGNIFICANCE: We provide a tool to convert pre-control nodule prevalence in adult males to mf prevalence in the general population, allowing historical data to be interpreted in terms of elimination prospects and disease burden of onchocerciasis. Furthermore, we identified significant geographical variation in mf prevalence and nodule prevalence patterns warranting further investigation of geographical differences in transmission patterns of onchocerciasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.