ArticlePloS one2013
Comparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of micro-osteoperforations on the gene expression profile of the periodontal ligament of orthodontically moved human teeth.Clinical oral investigations · 2022Trial
- Mechanism of ARPP21 antagonistic intron miR-128 on neurological function repair after stroke.Annals of clinical and translational neurology · 2021Article
- Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort.Frontiers in dental medicine · 2021Article
- Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption.Scientific reports · 2020Article
- Comparison of gene expression profiles between dental pulp and periodontal ligament tissues in humans.International journal of molecular medicine · 2017Article
- Elucidation of Gene Expression Patterns in the Brain after Spinal Cord Injury.Cell transplantation · 2017Article
- Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats.Frontiers in physiology · 2017Article
- Secretome Profiling of Periodontal Ligament from Deciduous and Permanent Teeth Reveals a Distinct Expression Pattern of Laminin Chains.PloS one · 2016Article
- Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children.Stem cells international · 2016Article
- Article
- Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp.Stem cells international · 2016Article
- Oculofaciocardiodental syndrome: novel BCOR mutations and expression in dental cells.Journal of human genetics · 2014Article
- ADAMTS-18: a metalloproteinase with multiple functions.Frontiers in bioscience (Landmark edition) · 2014Review
- Comparative gene-expression analysis of the dental follicle and periodontal ligament in humans.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are histological and functional differences between human deciduous and permanent periodontal ligament (PDL) tissues. The aim of this study was to determine the differences between these two types of tissue at the molecular level by comparing their gene expression patterns. PDL samples were obtained from permanent premolars (n = 38) and anterior deciduous teeth (n = 31) extracted from 40 healthy persons. Comparative cDNA microarray analysis revealed several differences in gene expression between the deciduous and permanent PDL tissues. These findings were verified by qRT-PCR (quantitative reverse-transcription-polymerase chain reaction) analysis, and the areas where genes are expressed were revealed by immunohistochemical staining. The expressions of 21 genes were up-regulated in deciduous relative to PDL tissues, and those of 30 genes were up-regulated in permanent relative to deciduous PDL tissues. The genes that were up-regulated in deciduous PDL tissues were those involved in the formation of the extracellular matrix (LAMC2, LAMB3, and COMP), tissue development (IGF2BP, MAB21L2, and PAX3), and inflammatory or immune reactions leading to tissue degradation (IL1A, CCL21, and CCL18). The up-regulated genes in permanent PDL tissues were related to tissue degradation (IL6 and ADAMTS18), myocontraction (PDE3B, CASQ2, and MYH10), and neurological responses (FOS, NCAM2, SYT1, SLC22A3, DOCK3, LRRTM1, LRRTM3, PRSS12, and ARPP21). The analysis of differential gene expressions between deciduous and permanent PDL tissues aids our understanding of histological and functional differences between them at the molecular level.
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