ArticlePloS one2013
Historical introgression of the downy mildew resistance gene Rpv12 from the Asian species Vitis amurensis into grapevine varieties.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 155 citations in OpenAlex.
- A novel resistance locus from an unexploited East Asian Vitis coignetiae confers resistance to grapevine downy mildew.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Defeated major resistance loci may act as Trojan horses compromising resistance pyramiding in grapevine.iScience · 2026Article
- Parallel adaptation and admixture drive the evolution of virulence in the grapevine downy mildew pathogen.PLoS pathogens · 2026Article
- Combined omics data reveal multilevel response to water deficit in grapevine disease-resistant varieties.Frontiers in plant science · 2026Article
- Review of the Pathogenic Mechanism of Grape Downy Mildew (Microorganisms · 2025Review
- Article
- The Transcriptional Landscape of Berry Skin in Red and White PIWI ("Pilzwiderstandsfähig") Grapevines Possessing QTLs for Partial Resistance to Downy and Powdery Mildews.Plants (Basel, Switzerland) · 2024Article
- A Sustainable Strategy for Marker-Assisted Selection (MAS) Applied in Grapevine (Plants (Basel, Switzerland) · 2024Article
- In Vitro Collection for the Safe Storage of Grapevine Hybrids and Identification of the Presence ofPlants (Basel, Switzerland) · 2024Article
- Novel loci associated with resistance to downy and powdery mildew in grapevine.Frontiers in plant science · 2024Article
- Breeding new seedless table grapevines for a more sustainable viticulture in Mediterranean climate.Frontiers in plant science · 2024Article
- Basic leucine zipper geneHorticulture research · 2023Article
- Fungicide-Saving Potential and Economic Advantages of Fungus-Resistant Grapevine Cultivars.Plants (Basel, Switzerland) · 2023Article
- HybridPlants (Basel, Switzerland) · 2023Article
- Discovery and genome-guided mapping ofHorticulture research · 2023Article
- Phased grapevine genome sequence of anFrontiers in plant science · 2023Article
- An in-planta comparative study of Plasmopara viticola proteome reveals different infection strategies towards susceptible and Rpv3-mediated resistance hosts.Scientific reports · 2022Article
- A cool climate perspective on grapevine breeding: climate change and sustainability are driving forces for changing varieties in a traditional market.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Phenotyping for QTL identification: A case study of resistance toFrontiers in plant science · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Amur grape (Vitis amurensis Rupr.) thrives naturally in cool climates of Northeast Asia. Resistance against the introduced pathogen Plasmopara viticola is common among wild ecotypes that were propagated from Manchuria into Chinese vineyards or collected by Soviet botanists in Siberia, and used for the introgression of resistance into wine grapes (Vitis vinifera L.). A QTL analysis revealed a dominant gene Rpv12 that explained 79% of the phenotypic variance for downy mildew resistance and was inherited independently of other resistance genes. A Mendelian component of resistance-a hypersensitive response in leaves challenged with P. viticola-was mapped in an interval of 0.2 cM containing an array of coiled-coil NB-LRR genes on chromosome 14. We sequenced 10-kb genic regions in the Rpv12(+) haplotype and identified polymorphisms in 12 varieties of V. vinifera using next-generation sequencing. The combination of two SNPs in single-copy genes flanking the NB-LRR cluster distinguished the resistant haplotype from all others found in 200 accessions of V. vinifera, V. amurensis, and V. amurensis x V. vinifera crosses. The Rpv12(+) haplotype is shared by 15 varieties, the most ancestral of which are the century-old 'Zarja severa' and 'Michurinets'. Before this knowledge, the chromosome segment around Rpv12(+) became introgressed, shortened, and pyramided with another downy mildew resistance gene from North American grapevines (Rpv3) only by phenotypic selection. Rpv12(+) has an additive effect with Rpv3(+) to protect vines against natural infections, and confers foliar resistance to strains that are virulent on Rpv3(+) plants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.