SynthesisPloS one2013
Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Associations of Polymorphisms in mir-196a2, mir-146a and mir-149 with Colorectal Cancer Risk: A Meta-Analysis.Pathology oncology research : POR · 2016Pooled it
- Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.PloS one · 2013Pooled it
- Association of MicroRNA-196a2 Variant with Response to Short-Acting β2-Agonist in COPD: An Egyptian Pilot Study.PloS one · 2016Trial
- Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications.Frontiers in molecular biosciences · 2025Review
- Explainable coronary artery disease prediction model based on AutoGluon from AutoML framework.Frontiers in cardiovascular medicine · 2024Article
- Article
- Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case-control study involving 2249 subjects.Bioscience reports · 2021Article
- Single nucleotide alterations in MicroRNAs and human cancer-A not fully explored field.Non-coding RNA research · 2020Review
- Somatic Mutations in miRNA Genes in Lung Cancer-Potential Functional Consequences of Non-Coding Sequence Variants.Cancers · 2019Article
- Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2018Review
- miR-300 rs12894467 polymorphism may be associated with susceptibility to primary lung cancer in the Chinese Han population.Cancer management and research · 2018Article
- A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility.OncoTargets and therapy · 2018Review
- rs11614913 polymorphism in miRNA-196a2 and cancer risk: an updated meta-analysis.OncoTargets and therapy · 2018Review
- miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives.Targeted oncology · 2017Review
- Increased Risk of Thai Childhood Acute Lymphoblastic Leukemia with the MiR196a2 T>C PolymorphismAsian Pacific journal of cancer prevention : APJCP · 2017Article
- MicroRNA-196a2 Biomarker and Targetome Network Analysis in Solid Tumors.Molecular diagnosis & therapy · 2016Article
- Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis.Journal of thoracic disease · 2016Article
- Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The relationship between genetic variants of XRCC1 gene and lung cancer susceptibility in Chinese Han population.Medical oncology (Northwood, London, England) · 2014Article
- Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection.Oncology letters · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association. METHODOLOGY/PRINCIPAL
findingsWe performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR = 1.26, 95% CI 1.07-1.49, P = 0.007; CC/CT vs. TT: OR = 1.13, 95% CI 0.98-1.29, P = 0.007; C vs. T: OR = 1.12, 95% CI 1.03-1.22, P = 0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR = 1.30, 95% CI 1.10-1.54, P = 0.003; CT vs. TT: OR = 1.16, 95% CI 1.01-1.34, P = 0.039; CC vs. CT/TT: OR = 1.21, 95% CI 1.04-1.41, P = 0.012; C vs. T: OR = 1.14, 95% CI 1.05-1.25, P = 0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR = 0.63, 95% CI 0.40-0.98, P = 0.040). No publication bias was found in this study. CONCLUSIONS/SIGNIFICANCE: Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.