ArticlePloS one2013
Prevalence of Porphyromonas gingivalis four rag locus genotypes in patients of orthodontic gingivitis and periodontitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Consequences of orthodontic treatment in malocclusion patients: clinical and microbial effects in adults and children.BMC oral health · 2016Trial
- Exploring the Genetic and Functional Diversity ofInternational journal of molecular sciences · 2025Article
- Effects of Oleanolic Acid Derived from Wine Pomace on Periodontopathic Bacterial Growth in Healthy Individuals: A Randomized Placebo-Controlled Study.Dentistry journal · 2024Article
- Prevalence and Phylogenetic Analysis of Lipoprotein-GeneAntibiotics (Basel, Switzerland) · 2023Article
- A comprehensive review on human disease-causing bacterial proteases and their impeding agents.Archives of microbiology · 2023Review
- Modulatory Mechanisms of Pathogenicity inMicroorganisms · 2022Review
- Self-ligating brackets exhibit accumulation of high levels of periodontopathogens in gingival crevicular fluid.Odontology · 2022Article
- The RagA and RagB proteins of Porphyromonas gingivalis.Molecular oral microbiology · 2021Review
- Oral dysbiosis induced byJournal of oral microbiology · 2020Article
- Clinical, microbiological, and immunological evaluation of patients in corrective orthodontic treatment.Progress in orthodontics · 2020Article
- Gingipain R1 and Lipopolysaccharide FromFrontiers in immunology · 2020Article
- Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis.Journal of dentistry (Shiraz, Iran) · 2018Article
- New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects.Frontiers in cellular and infection microbiology · 2018Article
- Distribution ofPeerJ · 2018Article
- Prevalence of fimA genotypes of Porphyromonas gingivalis in adolescent orthodontic patients.PloS one · 2017Article
- Profiling of subgingival plaque biofilm microbiota in adolescents after completion of orthodontic therapy.PloS one · 2017Article
- Control of white spot lesion adjacent to orthodontic bracket with use of fluoride varnish or chlorhexidine gel.TheScientificWorldJournal · 2015Article
- Orthodontic treatment with fixed appliances and biofilm formation--a potential public health threat?Clinical oral investigations · 2014Review
- Article
- Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections.BMC oral health · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis. Four rag locus variants are different in pathogenicity of Porphyromonas gingivalis. Moreover, there are different racial and geographic differences in distribution of rag locus genotypes. In this study, we assessed the prevalence of Porphyromonas gingivalis and rag locus genotypes in 102 gingival crevicular fluid samples from 57 cases of gingivitis patients with orthodontic appliances, 25 cases of periodontitis patients and 20 cases of periodontally healthy people through a 16S rRNA-based PCR and a multiplex PCR. The correlations between Porphyromona.gingivalis/rag locus and clinical indices were analyzed. The prevalence of Porphyromonas gingivalis and rag locus genes in periodontitis group was the highest among three groups and higher in orthodontic gingivitis than healthy people (p<0.01). An obviously positive correlation was observed between the prevalence of Porphyromonas gingivalis/rag locus and gingival index. rag-3 and rag-4 were the predominant genotypes in the patients of orthodontic gingivitis and mild-to-moderate periodontitis in Shandong. Porphyromonas.gingivalis carrying rag-1 has the strong virulence and could be associated with severe periodontitis.
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