ArticlePloS one2013
miRNA let-7e modulates the Wnt pathway and early nephrogenic markers in mouse embryonic stem cell differentiation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Peripheral blood miRNAs are associated with airflow below threshold in children with asthma.Respiratory research · 2025Article
- The function of miRNAs in the process of kidney development.Non-coding RNA research · 2023Review
- Vitexin Induces Apoptosis in MCF-7 Breast Cancer Cells through the Regulation of Specific miRNAs Expression.International journal of molecular and cellular medicine · 2022Article
- Biological Functions of Let-7e-5p in Promoting the Differentiation of MC3T3-E1 Cells.Frontiers in cell and developmental biology · 2021Article
- Comparative Gene Expression Profiling of Tobacco-Associated HPV-Positive versus Negative Oral Squamous Carcinoma Cell Lines.International journal of medical sciences · 2020Article
- miRNA profiling of small intestinal neuroendocrine tumors defines novel molecular subtypes and identifies miR-375 as a biomarker of patient survival.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Let-7b contributes to hepatocellular cancer progression through Wnt/β-catenin signaling.Saudi journal of biological sciences · 2018Article
- Comparison of multi-lineage differentiation of hiPSCs reveals novel miRNAs that regulate lineage specification.Scientific reports · 2018Article
- Downregulation of miR-638 promotes progression of breast cancer and is associated with prognosis of breast cancer patients.OncoTargets and therapy · 2018Article
- The Molecular Basis and Therapeutic Potential ofCanadian journal of gastroenterology & hepatology · 2018Review
- Decreased Expression of Plasma MicroRNA in Patients with Methamphetamine (MA) Use Disorder.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.Scientific reports · 2015Article
- Molecular convergence of neurodevelopmental disorders.American journal of human genetics · 2014Article
- MicroRNAs: modulators of cell identity, and their applications in tissue engineering.MicroRNA (Shariqah, United Arab Emirates) · 2014Review
- Stem cells in a three-dimensional scaffold environment.SpringerPlus · 2014Review
- Avian WNT4 in the female reproductive tracts: potential role of oviduct development and ovarian carcinogenesis.PloS one · 2013Article
- Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia.Asian journal of andrologyArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study indicates that embryonic stem cells [ESCs] cultured with retinoic acid and activin A significantly upregulate the miRNA let-7e. This specific miRNA modulates the Wnt pathway and the expression of early nephrogenic markers under these differentiation conditions. The differentiation markers WT1, Pax2 and Wnt4 were downregulated when miRNA let-7e was silenced, thus indicating the role of miRNA let-7e in the differentiation process. PKCβ, GSK3β phosphorylation (GSK3β(P)) and β-catenin expression was reduced in differentiated cells and reversed by miRNA let-7e silencing. Addition of a PKCβ inhibitor to the miRNA let-7e silenced cells abolished let-7e-derived effects in differentiation markers, and reversed the increase in GSK3β(P) and β-catenin, thus indicating that miRNA let-7e is involved in differentiation via the modulation of GSK3β phosphorylation and β-catenin production.
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