ArticlePloS one2013
The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis.International journal of colorectal disease · 2023Pooled it
- LEP gene variant is associated with prostate cancer but not with colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Leptin receptor gene (A/G) polymorphism rs1137101 and renal cell carcinoma.Molecular and cellular biochemistry · 2018Trial
- The association between hyperlipidemia and colorectal adenoma risk: a multivariable clinical study based on lipoprotein profile stratification.BMC gastroenterology · 2026Article
- Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.Cancer biology & medicine · 2023Article
- Leptin Signaling in Obesity and Colorectal Cancer.International journal of molecular sciences · 2022Review
- Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences.PloS one · 2019Article
- XRCC2 Polymorphisms and Environmental Factors Predict High Risk of Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Two-Sample Tests for High-Dimensional Linear Regression with an Application to Detecting Interactions.Statistica Sinica · 2018Article
- Effects of interactions between common genetic variants and smoking on colorectal cancer.BMC cancer · 2017Article
- Angiotensin-Converting Enzyme Gene Deletion Polymorphism is Associated with Lymph Node Metastasis in Colorectal Cancer Patients in a Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Article
- Genetic Variations inIranian journal of cancer prevention · 2016Article
- IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population.OncoTargets and therapy · 2015Article
- Genes associated with metabolic syndrome predict disease-free survival in stage II colorectal cancer patients. A novel link between metabolic dysregulation and colorectal cancer.Molecular oncology · 2014Article
- Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer.Iranian journal of cancer prevention · 2013Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPathologic condition associated with metabolic syndrome traits seems to increase the risk of colorectal cancer. One mechanism underlying this relationship may involve the growth-promoting effects of the circulation hormones associated with obesity and insulin resistance, such as leptin. METHODOLOGY/PRINCIPAL
findingsA two-stage case-control study was used to explore the role of polymorphisms of Leptin (LEP) and Leptin receptor (LEPR), either alone or in combination with environmental factors in colorectal carcinogenesis. In stage 1, 20 single nucleotide polymorphisms (SNPs) that tag common SNPs in these two genes were genotyped among 470 cases and 458 controls. In stage 2, another population with 314 cases and 355 controls were genotyped for the two most promising SNPs from stage 1. LEPR rs12037879 only presented modestly increased colorectal cancer risk, with odds ratios of 1.41 (95% confidence interval [CI] 1.13-1.76) and 1.74 (95%CI 1.08-2.81) for GA and AA genotype when compared with GG genotype in combined population. Smokers carrying LEPR rs12037879 A allele presented 1.67-fold (95%CI 1.39-fold to 2.01-fold) increased colorectal cancer risk when compared with non-smokers carrying GG genotype in combined analysis. Individuals with family history of cancer harboring LEPR rs12037879 A allele showed 1.52-fold (95%CI: 1.24-fold to 1.86-fold) increased colorectal cancer risk, compared with individuals without family history of cancer harboring GG genotype. Multifactor gene-environment interaction analysis revealed significant interactions among LEPR rs12037879, LEPR rs6690625, smoking status and family history of cancer, exhibiting a gradient of increased colorectal cancer risk along with the increasing number of risk factors (P = 9.82 × 10(-10)). CONCLUSIONS/SIGNIFICANCE: Our research supports that polymorphisms in LEPR may be associated with marginal increase in the risk for colorectal cancer. Moreover, this association could be strengthened by cigarette smoking and family history of cancer.
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