ArticlePloS one2013
Klebsiella phage vB_KleM-RaK2 - a giant singleton virus of the family Myoviridae.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 66 citations in OpenAlex.
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- Novel bacteriophages targeting wheat phyllosphere bacteria carry DNA modifications and single-strand breaks.Virus research · 2025Article
- Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024Review
- Exploring the enzymatic activity of depolymerase gp531 from Klebsiella pneumoniae jumbo phage RaK2.Virus research · 2023Article
- Characterization ofInternational journal of molecular sciences · 2023Article
- Phages against Noncapsulated Klebsiella pneumoniae: Broader Host range, Slower Resistance.Microbiology spectrum · 2023Article
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- Characterization of a novel genus of jumbo phages and their application in wastewater treatment.iScience · 2023Article
- Insights into theInternational journal of molecular sciences · 2023Article
- Characterization and genomic study of EJP2, a novel jumbo phage targeting antimicrobial resistantFrontiers in microbiology · 2023Article
- High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.Nature communications · 2022Article
- Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases.Biomolecules · 2022Article
- Metagenomic and metatranscriptomic insights into sulfate-reducing bacteria in a revegetated acidic mine wasteland.NPJ biofilms and microbiomes · 2022Article
- Functionalized Protein Nanotubes Based on the Bacteriophage vB_KleM-RaK2 Tail Sheath Protein.Nanomaterials (Basel, Switzerland) · 2021Article
- Article
- Article
- Phage phiKZ-The First of Giants.Viruses · 2021Review
- Jumbo Phages: A Comparative Genomic Overview of Core Functions and Adaptions for Biological Conflicts.Viruses · 2021Article
- Characterisation of Bacteriophage-Encoded Depolymerases Selective for KeyFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At 346 kbp in size, the genome of a jumbo bacteriophage vB_KleM-RaK2 (RaK2) is the largest Klebsiella infecting myovirus genome sequenced to date. In total, 272 out of 534 RaK2 ORFs lack detectable database homologues. Based on the similarity to biologically defined proteins and/or MS/MS analysis, 117 of RaK2 ORFs were given a functional annotation, including 28 RaK2 ORFs coding for structural proteins that have no reliable homologues to annotated structural proteins in other organisms. The electron micrographs revealed elaborate spike-like structures on the tail fibers of Rak2, suggesting that this phage is an atypical myovirus. While head and tail proteins of RaK2 are mostly myoviridae-related, the bioinformatics analysis indicate that tail fibers/spikes of this phage are formed from podovirus-like peptides predominantly. Overall, these results provide evidence that bacteriophage RaK2 differs profoundly from previously studied viruses of the Myoviridae family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.