ArticlePloS one2013
The yeast oxysterol binding protein Kes1 maintains sphingolipid levels.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Analysis of the ERG25 gene family based on the whole-genome sequence in Trametes versicolor and its response to light stress.Scientific reports · 2026Article
- Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms inIndian journal of microbiology · 2017Review
- OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites.Lipid insights · 2015Review
- OSBP-related proteins: liganding by glycerophospholipids opens new insight into their function.Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The oxysterol binding protein family are amphitropic proteins that bind oxysterols, sterols, and possibly phosphoinositides, in a conserved binding pocket. The Saccharomyces cerevisiae oxysterol binding protein family member Kes1 (also known as Osh4) also binds phosphoinositides on a distinct surface of the protein from the conserved binding pocket. In this study, we determine that the oxysterol binding protein family member Kes1 is required to maintain the ratio of complex sphingolipids and levels of ceramide, sphingosine-phosphate and sphingosine. This inability to maintain normal sphingolipid homeostasis resulted in misdistribution of Pma1, a protein that requires normal sphingolipid synthesis to occur to partition into membrane rafts at the Golgi for its trafficking to the plasma membrane.
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Registered trials
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