SynthesisPloS one2013
Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 8 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Cognitive reappraisal of food craving and emotions: a coordinate-based meta-analysis of fMRI studies.Social cognitive and affective neuroscience · 2024Pooled it
- A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System.Frontiers in nutrition · 2021Pooled it
- Hunger and BMI modulate neural responses to sweet stimuli: fMRI meta-analysis.International journal of obesity (2005) · 2020Pooled it
- The Neural Substrate of Reward Anticipation in Health: A Meta-Analysis of fMRI Findings in the Monetary Incentive Delay Task.Neuropsychology review · 2018Pooled it
- The Effects of rTMS on Impulsivity in Normal Adults: a Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- A quantitative and qualitative review of the effects of testosterone on the function and structure of the human social-emotional brain.Metabolic brain disease · 2016Pooled it
- The prevalence of food addiction as assessed by the Yale Food Addiction Scale: a systematic review.Nutrients · 2014Pooled it
- Reduced plasma interleukin-6 concentration after transcranial direct current stimulation to the prefrontal cortex.Behavioural brain research · 2024Trial
- Reduction in sugar drink valuation and consumption with gamified executive control training.Scientific reports · 2023Trial
- Effects of prefrontal theta burst stimulation on neuronal activity and subsequent eating behavior: an interleaved rTMS and fNIRS study.Social cognitive and affective neuroscience · 2023Trial
- Trial
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Signs of Warning: Do Health Warning Messages on Sweets Affect the Neural Prefrontal Cortex Activity?Nutrients · 2020Trial
- Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder.Psychiatry research. Neuroimaging · 2020Trial
- Weight gain is associated with changes in neural response to palatable food tastes varying in sugar and fat and palatable food images: a repeated-measures fMRI study.The American journal of clinical nutrition · 2019Trial
- Using neuroimaging to investigate the impact of Mandolean® training in young people with obesity: a pilot randomised controlled trial.BMC pediatrics · 2018Trial
- Pilot test of a novel food response and attention training treatment for obesity: Brain imaging data suggest actions shape valuation.Behaviour research and therapy · 2017Trial
- Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake.International journal of obesity (2005) · 2016Trial
- Amodal brain activation and functional connectivity in response to high-energy-density food cues in obesity.Obesity (Silver Spring, Md.) · 2014Trial
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesObesity is emerging as the most significant health concern of the twenty-first century. A wealth of neuroimaging data suggest that weight gain might be related to aberrant brain function, particularly in prefrontal cortical regions modulating mesolimbic addictive responses to food. Nevertheless, food addiction is currently a model hotly debated. Here, we conduct a meta-analysis of neuroimaging data, examining the most common functional differences between normal-weight and obese participants in response to food stimuli. DATA SOURCE: We conducted a search using several journal databases and adhered to the 'Preferred Reporting Items for Systematic Reviews and Meta-analyses' (PRISMA) method. To this aim, 10 studies were found with a total of 126 obese participants, 129 healthy controls, equaling 184 foci (146 increased, 38 decreased activation) using the Activation Likelihood Estimation (ALE) technique. Out of the 10 studies, 7 investigated neural responses to food versus non-food images.
resultsIn response to food images, obese in comparison to healthy weight subjects had increased activation in the left dorsomedial prefrontal cortex, right parahippocampal gyrus, right precentral gyrus and right anterior cingulate cortex, and reduced activation in the left dorsolateral prefrontal cortex and left insular cortex.
conclusionsPrefrontal cortex areas linked to cognitive evaluation processes, such as evaluation of rewarding stimuli, as well as explicit memory regions, appear most consistently activated in response to images of food in those who are obese. Conversely, a reduced activation in brain regions associated with cognitive control and interoceptive awareness of sensations in the body might indicate a weakened control system, combined with hypo-sensitivity to satiety and discomfort signals after eating in those who are prone to overeat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.