ArticlePloS one2013
Biosynthesis and thermal properties of PHBV produced from levulinic acid by Ralstonia eutropha.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 103 citations in OpenAlex.
- The Role of Polyhydroxyalkanoates in Veterinary Medicine: Biosynthesis, Material Modifications and Clinical Applications.Materials (Basel, Switzerland) · 2026Review
- Article
- Molecular Insights into Miscibility and Mechanical Modulation in PHBV/Chitosan Blends via Atomistic Simulations.Polymer · 2026Article
- Versatile sugar and valerate metabolic pathways in Paraburkholderia xenovorans LB400 enable tailored poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production.Applied microbiology and biotechnology · 2025Article
- Scalable Biosynthesis and Recovery of Poly-3-Hydroxybutyrate Produced from Cotton-Derived Glucose byPolymers · 2025Article
- Article
- Impact of Co-Substrates on the Production of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) byMaterials (Basel, Switzerland) · 2025Article
- Analysis of the response mechanism in lipid degradation of key gene LDH1 knockout strains of Saccharomyces cerevisiae under levulinic acid stress.Archives of microbiology · 2025Article
- Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds.Advanced healthcare materials · 2025Article
- Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.Polymer chemistry · 2025Review
- Improving Thermo-Sealing of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Blending with Polycaprolactone.Polymers · 2024Article
- Production of Poly(3-hydroxybutyrate-Bioengineering (Basel, Switzerland) · 2024Article
- Physicochemical characterization of polyhydroxybutyrate (PHB) produced by the rare halophile Brachybacterium paraconglomeratum MTCC 13074.Microbial cell factories · 2024Article
- Copolymers and Blends Based on 3-Hydroxybutyrate and 3-Hydroxyvalerate Units.International journal of molecular sciences · 2023Review
- Selective isolation and genomic characterization of biopolymer producer-a novel feature of halophile Brachybacterium paraconglomeratum MTCC 13074.Journal, genetic engineering & biotechnology · 2023Article
- Solid State Polymerization of Biodegradable Poly(butylene sebacate-co-terephthalate): A Rapid, Facile Method for Property Enhancement.Polymers · 2023Article
- The Role of Bacterial Polyhydroalkanoate (PHA) in a Sustainable Future: A Review on the Biological Diversity.International journal of environmental research and public health · 2023Review
- Biosynthesis and Properties of a P(3HB-Polymers · 2022Article
- Article
- Polyhydroxyalkanoates from a Mixed Microbial Culture: Extraction Optimization and Polymer Characterization.Polymers · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Levulinic acid (LA) can be cost-effectively produced from a vast array of renewable carbohydrate-containing biomaterials. LA could facilitate the commercialization of the polymer poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and PHBV-based products as carbon substrates. Therefore, this paper focused on the production of PHBV by Ralstonia eutropha with LA for hydroxyvalerate (HV) production, which plays an important role in enhancing the thermal properties of PHBV. Accordingly, the HV content of PHBV varied from 0-40.9% at different concentrations of LA. Stimulation of cell growth and PHBV accumulation were observed when 2-6 g L(-1) LA was supplied to the culture. The optimal nitrogen sources were determined to be 0.5 g L(-1) ammonium chloride and 2 g L(-1) casein peptone. It was determined that the optimal pH for cell growth and PHBV accumulation was 7.0. When the cultivation was performed in large scale (2 L fermenter) with a low DO concentration of 30% and a pH of 7.0, a high maximum dry cell weight of 15.53 g L(-1) with a PHBV concentration of 12.61 g L(-1) (53.9% HV), up to 81.2% of the dry cell weight, was obtained. The melting point of PHBV found to be decreased as the fraction of HV present in the polymer increased, which resulted in an improvement in the ductility and flexibility of the polymer. The results of this study will improve the understanding of the PHBV accumulation and production by R. eutropha and will be valuable for the industrial production of biosynthesized polymers.
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