ArticlePloS one2013
Retrospective analysis of prognostic factors in 205 patients with laryngeal squamous cell carcinoma who underwent surgical treatment.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- The Influence of Surgical Margins on Oncologic Outcomes in Advanced Laryngeal Cancer: A Systematic Review and Meta-analysis.Current oncology reports · 2026Pooled it
- The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Association of Charlson-Deyo Comorbidity Index With Survival Following Upfront Laryngectomy for Laryngeal Squamous Cell Carcinoma.Laryngoscope investigative otolaryngology · 2026Article
- A National Analysis of Microscopic Positive Margins in Oropharyngeal Cancer Patients Undergoing Transoral Robotic Surgery.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Long-term trends of laryngeal cancer incidence and mortality in China from 2004 to 2019 by region: age-period-cohort analysis and 15-years projections to 2034.Archives of public health = Archives belges de sante publique · 2026Article
- Differential IDH1 Immunohistochemical Expression Across the Pathologically Stratified Spectrum of Intraepithelial and Invasive Laryngeal Squamous Cell Lesions.Iranian journal of pathology · 2026Article
- Non-coding RNAs in laryngeal squamous cell carcinoma: diagnostic biomarkers and emerging exosome-based therapeutic strategies.Cancer cell international · 2025Review
- Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery.Scientific reports · 2025Article
- Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging.Diagnostics (Basel, Switzerland) · 2025Article
- The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disease 2021 research.Frontiers in oncology · 2025Article
- Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review.Non-coding RNA research · 2024Review
- HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.Functional & integrative genomics · 2024Article
- Transcriptional subtypes of glottic cancer characterized by differential activation of canonical oncogenic programming.Head & neck · 2023Article
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- A deep attention LSTM embedded aggregation network for multiple histopathological images.PloS one · 2023Article
- Expression and clinical significance of FGFR1 and FGFR2 in laryngeal squamous cell carcinoma.Translational cancer research · 2022Article
- Human Bone Marrow Mesenchymal Stem Cell (hBMSCs)-Derived miR-29a-3p-Containing Exosomes Impede Laryngocarcinoma Cell Malignant Phenotypes by Inhibiting PTEN.Stem cells international · 2022Article
- Sevoflurane promotes the apoptosis of laryngeal squamous cell carcinoma in-vitro and inhibits its malignant progression via miR-26a/FOXO1 axis.Bioengineered · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the most important factors affecting the prognosis of the patients with squamous cell carcinoma (SCC) of the larynx.
methodsBased on the clinical and follow-up data, 205 patients with SCC of the larynx receiving total laryngectomy, partial laryngectomy, or CO2 laser surgery in GuangDong General Hospital were retrospectively analyzed. A survival analysis was performed by the Kaplan-Meier method and a multivariable analysis of prognostic factors was carried out using the Cox proportional hazard model.
resultsSubtypes of carcinoma included 69.8% glottic and 30.2% supraglottic. Most patients were in N0 stage (77.6%), and 22.4% patients were in N1∼N3 stage. Over half of the patients were in T1∼T2 stage (55.1%), 20.0% in T3, and 24.9% in T4. Mean follow-up duration was 49.2 months. The survival rates 1, 2, and 3 years after the surgery were 99.0%, 91.7%, and 81.5%, respectively. The survival rate for those patients with clinical stage IV was significantly lower than for those with clinical stage I and II (p<0.001 and p = 0.013, respectively). The disease-free progression rates 1, 2, and 3 years after the surgery were 83.9%, 74.6%, and 71.2%, respectively. Futhermore, those patients with a Charlson score of 1 to 2 and ≥3 had higher risk of mortality than those with a Charlson score of 0 (hazard ratios of 1.8 and 2.41 p = 0.042 and p = 0.008). Multivariable analysis revealed that clinical stage, surgical margin, and comorbidity were significantly associated with both mortality and disease-free progression.
conclusionThe surgical resection margin, clinical stage, and comorbidity were independent factors affecting the laryngeal cancer prognosis. The survival rates were lower for patients with advanced laryngeal cancer, positive surgical margins, or severe comorbidity, suggesting the importance of early diagnosis, early treatment, negative surgical margins, and conditions of comorbidity.
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