ArticlePloS one2013
Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- The Hippo signaling pathway as a therapeutic target in Alzheimer's disease.Molecular neurodegeneration · 2025Review
- FERM domain-containing proteins are active components of the cell nucleus.Life science alliance · 2024Review
- FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression.Frontiers of medicine · 2023Article
- Implications of genetic variations, differential gene expression, and allele-specific expression on metformin response in drug-naïve type 2 diabetes.Journal of endocrinological investigation · 2023Article
- Article
- Development and validation of prognostic models for colon adenocarcinoma based on combined immune-and metabolism-related genes.Frontiers in oncology · 2022Article
- Review
- Review
- The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases.Journal of the peripheral nervous system : JPNS · 2021Review
- FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species.Cell and tissue research · 2020Article
- Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.Scientific reports · 2020Article
- Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity.Frontiers in cellular neuroscience · 2020Article
- The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin.Aging cell · 2019Article
- Activation mechanisms of the Hippo kinase signaling cascade.Bioscience reports · 2018Review
- Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling.Oxidative medicine and cellular longevity · 2018Article
- Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO.Allergy, asthma & immunology research · 2017Article
- Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy.Allergy, asthma & immunology research · 2017Article
- Article
- Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.Nature communications · 2016Article
- Willing to Be Involved in Cancer.Genes · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional co-activator YAP through Ser127 phosphorylation. This in turn suppresses the expression of genes involved in cell growth, proliferation and cancer development ensuring the control of organ size, cell contact inhibition and apoptosis. Here we show that in the mammalian sciatic nerve, Willin is predominantly expressed in fibroblasts and that Willin expression activates the Hippo signaling cascade and induces YAP translocation from the nucleus to the cytoplasm. In addition within these cells, although it inhibits cellular proliferation, Willin expression induces a quicker directional migration towards scratch closure and an increased expression of factors linked to nerve regeneration. These results show that Willin modulates sciatic nerve fibroblast activity indicating that Willin may have a potential role in the regeneration of the peripheral nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.