ArticlePLoS genetics2013
Extensive natural epigenetic variation at a de novo originated gene.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 127 citations in OpenAlex.
- Multi-locus models of deleterious epimutation-selection balance and the evolution of recombination modifiers.G3 (Bethesda, Md.) · 2026Article
- Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila.Molecular cell · 2025Article
- Deleterious mutation/epimutation-selection balance with and without inbreeding: a population (epi)genetics model.Genetics · 2024Article
- Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation.Plant communications · 2024Article
- Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation.G3 (Bethesda, Md.) · 2024Article
- RTEL1 is required for silencing and epigenome stability.Nucleic acids research · 2023Article
- CRISPR-Cas: A robust technology for enhancing consumer-preferred commercial traits in crops.Frontiers in plant science · 2023Review
- Heritable responses to stress in plants.Quantitative plant biology · 2023Review
- Single-cell genetic models to evaluate orphan gene function: The case of QQS regulating carbon and nitrogen allocation.Frontiers in plant science · 2023Article
- Epimutations and mutations, nurturing phenotypic diversity.Genetica · 2022Review
- Molecular mechanisms of transgenerational epigenetic inheritance.Nature reviews. Genetics · 2022Review
- Epigenome editing: targeted manipulation of epigenetic modifications in plants.Genes & genomics · 2022Review
- Research Advances and Prospects of Orphan Genes in Plants.Frontiers in plant science · 2022Review
- Epigenetics and its role in effecting agronomical traits.Frontiers in plant science · 2022Review
- Review
- The Underlying Nature of Epigenetic Variation: Origin, Establishment, and Regulatory Function of Plant Epialleles.International journal of molecular sciences · 2021Review
- Natural epialleles of Arabidopsis SUPERMAN display superwoman phenotypes.Communications biology · 2020Article
- Quantitative Epigenetics: A New Avenue for Crop Improvement.Epigenomes · 2020Review
- A genome assembly and the somatic genetic and epigenetic mutation rate in a wild long-lived perennial Populus trichocarpa.Genome biology · 2020Article
- Mild drought in the vegetative stage induces phenotypic, gene expression, and DNA methylation plasticity in Arabidopsis but no transgenerational effects.Journal of experimental botany · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic variation, such as heritable changes of DNA methylation, can affect gene expression and thus phenotypes, but examples of natural epimutations are few and little is known about their stability and frequency in nature. Here, we report that the gene Qua-Quine Starch (QQS) of Arabidopsis thaliana, which is involved in starch metabolism and that originated de novo recently, is subject to frequent epigenetic variation in nature. Specifically, we show that expression of this gene varies considerably among natural accessions as well as within populations directly sampled from the wild, and we demonstrate that this variation correlates negatively with the DNA methylation level of repeated sequences located within the 5'end of the gene. Furthermore, we provide extensive evidence that DNA methylation and expression variants can be inherited for several generations and are not linked to DNA sequence changes. Taken together, these observations provide a first indication that de novo originated genes might be particularly prone to epigenetic variation in their initial stages of formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.