ArticleThe Clinical biochemist. Reviews2013
Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?
Article in The Clinical biochemist. Reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3Immunologic research · 2017Trial
- The role of vitamin D deficiency in the development and severity of oral lichen planus: a case-control study.Clinical oral investigations · 2025Article
- Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse.International journal of molecular sciences · 2023Article
- Genetic, Environmental and Lifestyle Determinants of Accelerated Telomere Attrition as Contributors to Risk and Severity of Multiple Sclerosis.Biomolecules · 2021Review
- The Influence of Sunlight Exposure and Sun Protecting Behaviours on Allergic Outcomes in Early Childhood.International journal of environmental research and public health · 2021Article
- Altitude conditions seem to determine the evolution of COVID-19 in Brazil.Scientific reports · 2021Article
- Vitamin D Status and Its Consequences for Health in South Africa.International journal of environmental research and public health · 2016Review
- Latitude, sun exposure and vitamin D supplementation: associations with quality of life and disease outcomes in a large international cohort of people with multiple sclerosis.BMC neurology · 2015Article
- Vitamin D and the Development of Atopic Eczema.Journal of clinical medicine · 2015Review
- Can skin exposure to sunlight prevent liver inflammation?Nutrients · 2015Review
- A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Vitamin D and inflammation.Dermato-endocrinologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced immunity following exposure of skin to UV radiation (UVR) may explain the positive latitude gradient measured for a number of autoimmune diseases (greater incidence of disease with residence at higher latitudes), including multiple sclerosis, allergic asthma and diabetes. Humans obtain >80% of their vitamin D3 by exposure of skin to UVR in sunlight. In experimental models, both vitamin D3-dependent and vitamin D3-independent pathways have been implicated in the mechanisms of UVR-induced systemic suppression of immunity. However, where does the balance of control lie? How important is vitamin D3 other than providing a biomarker of sun exposure? Are other molecules/pathways activated by UVR more important? Murine and human studies suggest many molecules may play a role and their participation may vary with different diseases and the time of UVR exposure or vitamin D3 sufficiency/deficiency. Although low vitamin D3 levels have been associated with increased prevalence and progression of human autoimmune diseases, the benefits of supplementation with vitamin D3 have not been definitive. Vitamin D3 levels are a measure of past sun exposure but vitamin D3-dependent and vitamin D3-independent immunosuppressive effects of UVR may play a role in control of autoimmune diseases.
Identifiers
23592888PMC3626364W1497174884What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.