ArticleThe Journal of biological chemistry2013
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Genomic advances in the study of the mosquito vector during avian malaria infection.Parasitology · 2023Review
- The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes.Open biology · 2022Article
- Silencing Transglutaminase GenesInsects · 2022Article
- Transglutaminase 3 negatively regulates immune responses on the heart of the mosquito, Anopheles gambiae.Scientific reports · 2022Article
- Article
- The Route of Infection Influences the Contribution of Key Immunity Genes to Antibacterial Defense in Anopheles gambiae.Journal of innate immunity · 2021Article
- JNK signaling regulates oviposition in the malaria vector Anopheles gambiae.Scientific reports · 2020Article
- Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development.Nature communications · 2019Article
- Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.Scientific reports · 2019Article
- Plasmodium berghei P47 is essential for ookinete protection from the Anopheles gambiae complement-like response.Scientific reports · 2017Article
- Arthropod Innate Immune Systems and Vector-Borne Diseases.Biochemistry · 2017Review
- Microbial Pre-exposure and Vectorial Competence ofFrontiers in cellular and infection microbiology · 2017Article
- Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes.Scientific reports · 2016Article
- Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3.Malaria journal · 2014Article
- Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease.Annual review of immunology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anopheline mosquitoes are the only vectors of human malaria worldwide. It is now widely accepted that mosquito immune responses play a crucial role in restricting Plasmodium development within the vector; therefore, further dissection of the molecular mechanisms underlying these processes should inform new vector control strategies urgently needed to roll back the disease. Here, using genome-wide transcriptional profiling, bioinformatics, and functional gene analysis, we identify a new axis of mosquito resistance to monoclonal Plasmodium falciparum infections that includes the AP-1 transcription factor Fos and the transglutaminase 2 (TGase2), a cross-linking enzyme with known roles in wound responses. We demonstrate that Fos regulates induction of TGase2 expression after wounding but does not affect expression of the components of the well characterized complement-like system. Silencing of Fos or of TGase2 aborts the wounding-induced mosquito killing of P. falciparum. These results reveal multiple signaling pathways that are required for efficient Plasmodium killing in Anopheles gambiae.
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