ArticleThe Journal of biological chemistry2013
Structural mechanism of ring-opening reaction of glucose by human serum albumin.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 126 citations in OpenAlex.
- Article
- Diabetic Glycation of Human Serum Albumin Affects Its Immunogenicity.Biomolecules · 2024Article
- The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding.International journal of molecular sciences · 2024Article
- Crystal structures of human serum albumin in complex with lysophosphatidylcholine.Biophysical journal · 2023Article
- A novel polysaccharide/zein conjugate as an alternative green plastic.Scientific reports · 2023Article
- Binding of Apo and Glycated Human Serum Albumins to an Albumin-Selective Aptamer-Bound Graphene Quantum Dot Complex.ACS omega · 2023Article
- Site Identification by Ligand Competitive Saturation-Biologics Approach for Structure-Based Protein Charge Prediction.Molecular pharmaceutics · 2023Article
- Article
- Biophysical, Biochemical, and Molecular Docking Investigations of Anti-Glycating, Antioxidant, and Protein Structural Stability Potential of Garlic.Molecules (Basel, Switzerland) · 2022Article
- Comprehensive overview of human serum albumin glycation in diabetes mellitus.World journal of diabetes · 2021Review
- Glycated Hemoglobin and Methods for Its Point of Care Testing.Biosensors · 2021Article
- 3,3'-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells.Environmental science & technology · 2020Article
- Discovery of [1,2,3]triazolo[4,5-Acta pharmaceutica Sinica. B · 2020Article
- Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.Journal of medicinal chemistry · 2020Article
- Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins.Chemical science · 2019Article
- Capping gold nanoparticles with albumin to improve their biomedical properties.International journal of nanomedicine · 2019Review
- Article
- Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate.Biochemistry and biophysics reports · 2018Article
- Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study.Journal of pharmaceutical analysis · 2018Article
- Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose reacts with proteins nonenzymatically under physiological conditions. Such glycation is exacerbated in diabetic patients with high levels of blood sugar and induces various complications. Human albumin serum (HSA) is the most abundant protein in plasma and is glycated by glucose. The glycation sites on HSA remain controversial among different studies. Here, we report two protein crystal structures of HSA in complex with either glucose or fructose. These crystal structures reveal the presence of linear forms of sugar for both monosaccharides. The linear form of glucose forms a covalent bond to Lys-195 of HSA, but this is not the case for fructose. Based on these structures, we propose a mechanism for glucose ring opening involving both residues Lys-195 and Lys-199. These results provide mechanistic insights to understand the glucose ring-opening reaction and the glycation of proteins by monosaccharides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.