ArticleProceedings of the National Academy of Sciences of the United States of America2013
Tertiary model of a plant cellulose synthase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 169 citations in OpenAlex.
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- Cellulose Synthesis in Cyanobacteria: Shared Pathways and Distinct Features with Bacteria and Plants.Plants (Basel, Switzerland) · 2025Review
- Empirical evidence that glucan-interacting amino acid side chains within the transmembrane channel collectively facilitate cellulose synthase function.Plant molecular biology · 2025Article
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- CslA and GlxA fromApplied and environmental microbiology · 2024Article
- Discovery and Characterization of Fluopipamine, a Putative Cellulose Synthase 1 Antagonist withinJournal of agricultural and food chemistry · 2024Article
- Enzymes in 3D: Synthesis, remodelling, and hydrolysis of cell wall (1,3;1,4)-β-glucans.Plant physiology · 2023Article
- Review
- Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8.Structure (London, England : 1993) · 2023Article
- Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8.bioRxiv : the preprint server for biology · 2023Article
- 2-NBDG Uptake inFrontiers in plant science · 2023Article
- CRISPR/Cas9-mediated P-CR domain-specific engineering of CESA4 heterodimerization capacity alters cell wall architecture and improves saccharification efficiency in poplar.Plant biotechnology journal · 2022Article
- Solid-State NMR Investigations of Extracellular Matrixes and Cell Walls of Algae, Bacteria, Fungi, and Plants.Chemical reviews · 2022Review
- Species-Specific Gene Expansion of theFrontiers in plant science · 2022Article
- Phenotypic effects of changes in the FTVTxK region of anPlant direct · 2021Article
- Updating Insights into the Catalytic Domain Properties of PlantMolecules (Basel, Switzerland) · 2021Review
- Understanding In Vitro Tissue Culture-Induced Variation Phenomenon in Microspore System.International journal of molecular sciences · 2021Review
- Structure ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
Abstract
A 3D atomistic model of a plant cellulose synthase (CESA) has remained elusive despite over forty years of experimental effort. Here, we report a computationally predicted 3D structure of 506 amino acids of cotton CESA within the cytosolic region. Comparison of the predicted plant CESA structure with the solved structure of a bacterial cellulose-synthesizing protein validates the overall fold of the modeled glycosyltransferase (GT) domain. The coaligned plant and bacterial GT domains share a six-stranded β-sheet, five α-helices, and conserved motifs similar to those required for catalysis in other GT-2 glycosyltransferases. Extending beyond the cross-kingdom similarities related to cellulose polymerization, the predicted structure of cotton CESA reveals that plant-specific modules (plant-conserved region and class-specific region) fold into distinct subdomains on the periphery of the catalytic region. Computational results support the importance of the plant-conserved region and/or class-specific region in CESA oligomerization to form the multimeric cellulose-synthesis complexes that are characteristic of plants. Relatively high sequence conservation between plant CESAs allowed mapping of known mutations and two previously undescribed mutations that perturb cellulose synthesis in Arabidopsis thaliana to their analogous positions in the modeled structure. Most of these mutation sites are near the predicted catalytic region, and the confluence of other mutation sites supports the existence of previously undefined functional nodes within the catalytic core of CESA. Overall, the predicted tertiary structure provides a platform for the biochemical engineering of plant CESAs.
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