ArticleObesity (Silver Spring, Md.)2013
Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery.
Article in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Evidence of Bariatric Surgery Benefits Cardiac Function in Non-HFpEF Patients with Obesity: a Meta-Analysis.Obesity surgery · 2023Pooled it
- Maternal Cardiac Function in Pregnancies with Metabolic Disorders.European cardiology · 2024Review
- Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.International journal of molecular sciences · 2022Review
- Role of the Autonomic Nervous System in Mechanism of Energy and Glucose Regulation Post Bariatric Surgery.Frontiers in neuroscience · 2021Review
- Severity Indices for Obstructive Sleep Apnea Syndrome Reflecting Glycemic Control or Insulin Resistance.Internal medicine (Tokyo, Japan) · 2019Article
- Adrenomedullary function, obesity and permissive influences of catecholamines on body mass in patients with chromaffin cell tumours.International journal of obesity (2005) · 2019Article
- Early blood pressure response to isometric exercise is attenuated in obese individuals who have undergone bariatric surgery.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal.Physiological reports · 2017Article
- Blunting of adaptive thermogenesis as a potential additional mechanism to promote weight loss after gastric bypass.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Article
- Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice.Disease models & mechanisms · 2017Article
- The Role of the Autonomic Nervous System in the Pathophysiology of Obesity.Frontiers in physiology · 2017Review
- Higher Blood Pressure Partially Links Greater Adiposity to Reduced Brain White Matter Integrity.American journal of hypertension · 2016Article
- Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Gastrointestinal intervention ameliorates high blood pressure through antagonizing overdrive of the sympathetic nerve in hypertensive patients and rats.Journal of the American Heart Association · 2014Article
- Acute cyclooxygenase inhibition does not alter muscle sympathetic nerve activity or forearm vasodilator responsiveness in lean and obese adults.Physiological reports · 2014Article
- Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity.International journal of endocrinology · 2013Review
- Predicted vs. Actual Resting Energy Expenditure and Activity Coefficients: Post-Gastric Bypass, Lean and Obese Women.Obesity & control therapies : open accessArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis study was designed to determine how gastric bypass affects the sympathetically-mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA). DESIGN AND
methodsWe measured REE before and after beta-blockade in seventeen female subjects approximately three years post-gastric bypass surgery and in nineteen female obese individuals for comparison. We also measured MSNA in a subset of these subjects.
resultsThe gastric bypass subjects had no change in REE after systemic beta-blockade, reflecting a lack of sympathetic support of REE, in contrast to obese subjects where REE was reduced by beta-blockade by approximately 5% (P < 0.05). The gastric bypass subjects, while still overweight (BMI = 29.3 vs 38.0 kg·m(-2) for obese subjects, P < 0.05), also had significantly lower MSNA compared to obese subjects (10.9 ± 2.3 vs. 21.9 ± 4.1 bursts·min(-1) , P < 0.05). The reasons for low MSNA and a lack of sympathetically mediated support of REE after gastric bypass are likely multifactorial and may be related to changes in insulin sensitivity, body composition, and leptin, among other factors.
conclusionsThese findings may have important consequences for the maintenance of weight loss after gastric bypass. Longitudinal studies are needed to further explore the changes in sympathetic support of REE and if changes in MSNA or tissue responsiveness are related to the sympathetic support of REE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.