ArticleAmerican journal of epidemiology2013
Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- Impact of mupirocin resistance on the transmission and control of healthcare-associated MRSA.The Journal of antimicrobial chemotherapy · 2015Pooled it
- Inferring asymptomatic carriers of antimicrobial-resistant organisms in hospitals using genomic, microbiological and patient mobility data.Nature communications · 2025Article
- System identifiability in a time-evolving agent-based model.PloS one · 2024Article
- Bayesian Calibration to Address the Challenge of Antimicrobial Resistance: A Review.IEEE access : practical innovations, open solutions · 2024Article
- Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting.BMC medicine · 2023Article
- Ensemble inference of unobserved infections in networks using partial observations.PLoS computational biology · 2023Article
- Challenges in Forecasting Antimicrobial Resistance.Emerging infectious diseases · 2023Review
- Routes of transmission of VIM-positive Pseudomonas aeruginosa in the adult intensive care unit-analysis of 9 years of surveillance at a university hospital using a mathematical model.Antimicrobial resistance and infection control · 2022Article
- Risk-aware temporal cascade reconstruction to detect asymptomatic cases.Knowledge and information systems · 2022Article
- Identifying asymptomatic spreaders of antimicrobial-resistant pathogens in hospital settings.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Association Between Contact Precautions and Transmission of Methicillin-Resistant Staphylococcus aureus in Veterans Affairs Hospitals.JAMA network open · 2021Article
- Effectiveness of Contact Precautions to Prevent Transmission of Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci in Intensive Care Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Article
- Tracking Pseudomonas aeruginosa transmissions due to environmental contamination after discharge in ICUs using mathematical models.PLoS computational biology · 2019Article
- Article
- Extended models for nosocomial infection: parameter estimation and model selection.Mathematical medicine and biology : a journal of the IMA · 2018Article
- The Transmissibility of Antibiotic-Resistant Enterobacteriaceae in Intensive Care Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Point-of-care universal screening for meticillin-resistant Staphylococcus aureus: a cluster-randomized cross-over trial.The Journal of hospital infection · 2017Article
- A Dynamic Transmission Model to Evaluate the Effectiveness of Infection Control Strategies.Open forum infectious diseases · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Infection control for hospital pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) often takes the form of a package of interventions, including the use of patient isolation and decolonization treatment. Such interventions, though widely used, have generated controversy because of their significant resource implications and the lack of robust evidence with regard to their effectiveness at reducing transmission. The aim of this study was to estimate the effectiveness of isolation and decolonization measures in reducing MRSA transmission in hospital general wards. Prospectively collected MRSA surveillance data from 10 general wards at Guy's and St. Thomas' hospitals, London, United Kingdom, in 2006-2007 were used, comprising 14,035 patient episodes. Data were analyzed with a Markov chain Monte Carlo algorithm to model transmission dynamics. The combined effect of isolation and decolonization was estimated to reduce transmission by 64% (95% confidence interval: 37, 79). Undetected MRSA-positive patients were estimated to be the source of 75% (95% confidence interval: 67, 86) of total transmission events. Isolation measures combined with decolonization treatment were strongly associated with a reduction in MRSA transmission in hospital general wards. These findings provide support for active methods of MRSA control, but further research is needed to determine the relative importance of isolation and decolonization in preventing transmission.
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