ArticleMolecular & cellular proteomics : MCP2013
Discovery of histone modification crosstalk networks by stable isotope labeling of amino acids in cell culture mass spectrometry (SILAC MS).
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Synergistic function of RNA modifications inaBIOTECH · 2025Article
- Is There a Histone Code for Cellular Quiescence?Frontiers in cell and developmental biology · 2021Review
- Middle-down proteomics: a still unexploited resource for chromatin biology.Expert review of proteomics · 2017Review
- Co-occurring protein phosphorylation are functionally associated.PLoS computational biology · 2017Article
- Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.Nature biotechnology · 2016Article
- Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation.Molecular & cellular proteomics : MCP · 2016Article
- The interplay of histone modifications - writers that read.EMBO reports · 2015Review
- Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation.The EMBO journal · 2015Article
- Quantitative proteomic analysis of histone modifications.Chemical reviews · 2015Review
- Systematic characterization and prediction of post-translational modification cross-talk.Molecular & cellular proteomics : MCP · 2015Article
- SILAC peptide ratio calculator: a tool for SILAC quantitation of peptides and post-translational modifications.Journal of proteome research · 2014Article
- Sites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling.Molecular and cellular biology · 2013Article
- Proteomic characterization of novel histone post-translational modifications.Epigenetics & chromatin · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this paper we describe an approach that combines stable isotope labeling of amino acids in cells culture, high mass accuracy liquid chromatography tandem mass spectrometry and a novel data analysis approach to accurately determine relative peptide post-translational modification levels. This paper describes the application of this approach to the discovery of novel histone modification crosstalk networks in Saccharomyces cerevisiae. Yeast histone mutants were generated to mimic the presence/absence of 44 well-known modifications on core histones H2A, H2B, H3, and H4. In each mutant strain the relative change in H3 K79 methylation and H3 K56 acetylation were determined using stable isotope labeling of amino acids in cells culture. This approach showed relative changes in H3 K79 methylation and H3 K56 acetylation that are consistent with known histone crosstalk networks. More importantly, this study revealed additional histone modification sites that affect H3 K79 methylation and H3 K56 acetylation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.