ArticleClinical rheumatology2013
Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever.
Article in Clinical rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Investigation of Microvascular Involvement Through Nailfold Capillaroscopic Examination in Children with Familial Mediterranean Fever.Medicina (Kaunas, Lithuania) · 2025Article
- Evaluation of Hematological Parameters as Markers for Subclinical Inflammation in Adults with Familial Mediterranean Fever.Middle East journal of digestive diseases · 2024Article
- Early Versus Late Onset Familial Mediterranean Fever: Similarities, Discrepancies, and the Value of Neutrophil to Lymphocyte Ratio in Detecting Autoinflammation.Journal of clinical practice and research · 2024Article
- Higher neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width are associated with postoperative delirium in patients undergoing esophagectomy: a retrospective observational study.Journal of anesthesia · 2022Observational
- The effectiveness of anti-interleukin-1 therapy on subclinical inflammation parameters during the attack-free period in familial Mediterranean fever patients: A case-control study.Turkish journal of medical sciences · 2022Article
- Associations of platelet indices with proteinuria and chronic kidney disease.The Journal of international medical research · 2020Article
- Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart - Review Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Evaluation of hematological parameters in children with FMF.Clinical rheumatology · 2019Article
- Cardiovascular disease in patients with autoinflammatory syndromes.Rheumatology international · 2018Review
- The Broad-Ranging Panorama of Systemic Autoinflammatory Disorders with Specific Focus on Acute Painful Symptoms and Hematologic Manifestations in Children.Mediterranean journal of hematology and infectious diseases · 2018Review
- Association of mean platelet volume with incident type 2 diabetes mellitus risk: the Dongfeng-Tongji cohort study.Diabetology & metabolic syndrome · 2018Article
- Assessment of neutrophil to lymphocyte ratio and mean platelet volume in pediatric familial Mediterranean fever patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Evaluation of subclinical inflammation in familial Mediterranean fever patients: relations with mutation types and attack status: a retrospective study.Clinical rheumatology · 2016Article
- The Relationship Among the Level of Serum Amyloid A, High-Density Lipoprotein and Microalbuminuria in Patients With Familial Mediterranean Fever.Journal of clinical laboratory analysis · 2016Article
- Red cell distribution width is associated with albuminuria in adults with familial Mediterranean fever.The Kaohsiung journal of medical sciences · 2016Article
- Reduction in mean platelet volume in children with acute bronchiolitis.Turk pediatri arsivi · 2016Article
- Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Assessing disease severity and activity in patients with familial Mediterranean fever.Inflammation · 2014Article
- Mean platelet volume as an indicator of disease activity in juvenile SLE.Clinical rheumatology · 2014Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
This study aims to compare the mean platelet volume (MPV) levels in children and adults diagnosed with familial Mediterranean fever (FMF) during attack-free periods in order to find out whether it reflects the emergence of microalbuminuria/proteinuria and the development of amyloidosis or not. The study consisted of 63 pediatric patients (group 1), 50 adult patients (group 2), 50 healthy children (group 3), and 43 healthy adults (group 4). Demographic data, age at diagnosis, duration of the disease and colchicine treatment, and FMF gene mutations were recorded, and erythrocyte sedimentation rate, C-reactive protein, fibrinogen, hemoglobin, white blood cell count, platelet count, MPV, blood urea nitrogen, creatine, albumin, and urine microalbumin and protein levels were evaluated. According to the presence of microalbuminuria/proteinuria, patient groups were subgrouped into two by themselves as pediatric and adult groups with and without proteinuria. The most frequent mutation was M694V. MPV was significantly higher in FMF patients than those in the healthy control groups. Microalbuminuria/proteinuria were detected in 18 (28.57 %) of 63 pediatric patients and 26 (52 %) of 50 adult patients. Amyloidosis has been identified in 3 (16.6 %) of 18 pediatric patients and 18 (69.23 %) of 26 adult patients with proteinuria. Subgroup comparisons revealed that MPV levels were significantly higher in patients with proteinuria than patients without proteinuria in both pediatric and adult groups. Moreover, MPV levels were also significantly higher in adult patients with or without proteinuria than in pediatric patients with or without proteinuria. There were significant differences in terms of serum albumin levels between the groups with and without proteinuria as expected. The increase in MPV over the years of the disease, especially in groups with proteinuria, may be an important predictor of continuing increase of subclinical inflammation, the emergence of the microalbuminuria/proteinuria, and the developing of amyloidosis, but further studies are needed in order to support this proposal.
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