ReviewDevelopmental biology2013
The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns.
Review in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Interacting Fat1 and Dchs Planar Cell Polarity Proteins Supported by Fjx1 Serve as Heterodimeric Intercellular Bridges Crucial to Support Spermatogenesis.Advances in experimental medicine and biology · 2025Review
- New Horizons in Cancer Progression and Metastasis:Biomedicines · 2024Review
- Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.Journal of developmental biology · 2024Review
- Effects of shikonin on the development of ovarian follicles and female germline stem cells.The Journal of international medical research · 2021Article
- Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands.Developmental cell · 2020Article
- Planar cell polarity: theDevelopment (Cambridge, England) · 2018Article
- Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner.Nature communications · 2018Article
- Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis.PLoS biology · 2018Article
- Active epithelial Hippo signaling in idiopathic pulmonary fibrosis.JCI insight · 2018Article
- MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation.Biology open · 2017Article
- Planar cell polarity in development and disease.Nature reviews. Molecular cell biology · 2017Review
- Planar cell polarity: global inputs establishing cellular asymmetry.Current opinion in cell biology · 2017Review
- The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.The Journal of cell biology · 2017Article
- A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings.G3 (Bethesda, Md.) · 2016Article
- Planar cell polarity of the kidney.Experimental cell research · 2016Review
- Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila.Biology open · 2016Article
- Article
- Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.Developmental cell · 2015Article
- Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).Annual review of cell and developmental biology · 2015Review
- Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.Developmental biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Planar cell polarity (PCP) is a small but important area of research. In this review we discuss a limited number of topics within the PCP field, chosen because they are difficult, unsolved, controversial or just because we find them interesting. Because Drosophila is the best studied and technically most amenable system we have concentrated on it, but also consider some examples from work on vertebrates. Topics discussed include the number of genetic pathways involved in PCP, as well as the causal relationship between embryonic axes, gradients of morphogens and PCP itself. We consider the vexed question of the roles of the Wnt genes in PCP in both vertebrates and Drosophila. We discuss whether the proteins involved in PCP need to be localised asymmetrically in cells in order to function. We criticise the way the Hippo pathway is described in the literature and ask what its wildtype function is. We explore afresh how the Hippo pathway might be linked both to growth and to PCP through the gigantic cadherin molecule Fat. We offer some new ways of making sense of published results, particularly those relating to the Frizzled/Starry night and Dachsous/Fat systems of PCP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.