ArticlePlanta2013
Medicago glucosyltransferase UGT72L1: potential roles in proanthocyanidin biosynthesis.
Article in Planta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Proanthocyanidins: structure, biosynthesis, regulation, and structure-activity relationships.aBIOTECH · 2026Review
- Dual regulation of anthocyanins and proanthocyanidins by PpBL and its linkage to acidity in peach.Molecular horticulture · 2026Article
- Review
- Comparative transcriptome analysis identifies candidate genes related to seed coat color in rapeseed.Frontiers in plant science · 2023Article
- Chemical Diversity of Flavan-3-Ols in Grape Seeds: Modulating Factors and Quality Requirements.Plants (Basel, Switzerland) · 2022Review
- UGT72, a Major Glycosyltransferase Family for Flavonoid and Monolignol Homeostasis in Plants.Biology · 2022Review
- Seed-coat protective neolignans are produced by the dirigent protein AtDP1 and the laccase AtLAC5 in Arabidopsis.The Plant cell · 2021Article
- Tandem UGT71B5s Catalyze Lignan Glycosylation inFrontiers in plant science · 2021Article
- Flavanol Glycoside Content of Grape Seeds and Skins ofMolecules (Basel, Switzerland) · 2019Article
- Identification and Quantification of Flavanol Glycosides inMolecules (Basel, Switzerland) · 2018Article
- Advances in the MYB-bHLH-WD Repeat (MBW) Pigment Regulatory Model: Addition of a WRKY Factor and Co-option of an Anthocyanin MYB for Betalain Regulation.Plant & cell physiology · 2017Review
- De novo sequencing and comparative analysis of leaf transcriptomes of diverse condensed tannin-containing lines of underutilized Psophocarpus tetragonolobus (L.) DC.Scientific reports · 2017Article
- A Snapshot of Functional Genetic Studies in Medicago truncatula.Frontiers in plant science · 2016Review
- LACCASE5 is required for lignification of the Brachypodium distachyon Culm.Plant physiology · 2015Article
- The MYB182 protein down-regulates proanthocyanidin and anthocyanin biosynthesis in poplar by repressing both structural and regulatory flavonoid genes.Plant physiology · 2015Article
- Lignin engineering through laccase modification: a promising field for energy plant improvement.Biotechnology for biofuels · 2015Review
- Article
- MYB5 and MYB14 Play Pivotal Roles in Seed Coat Polymer Biosynthesis in Medicago truncatula.Plant physiology · 2014Article
- Proanthocyanidin oxidation of Arabidopsis seeds is altered in mutant of the high-affinity nitrate transporter NRT2.7.Journal of experimental botany · 2014Article
- The tannosome is an organelle forming condensed tannins in the chlorophyllous organs of Tracheophyta.Annals of botany · 2013Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the first reaction specific for proanthocyanidin (PA) biosynthesis in Arabidopsis thaliana and Medicago truncatula, anthocyanidin reductase (ANR) converts cyanidin to (-)-epicatechin. The glucosyltransferase UGT72L1 catalyzes formation of epicatechin 3'-O-glucoside (E3'OG), the preferred substrate for MATE transporters implicated in PA biosynthesis in both species. The mechanism of PA polymerization is still unclear, but may involve the laccase-like polyphenol oxidase TRANSPARENT TESTA 10 (TT10). We have employed a combination of cell biological, biochemical and genetic approaches to evaluate this PA pathway model. The promoter regions of UGT72L1 and MtANR share common cis-acting elements and direct overlapping, but partially distinct, expression patterns. UGT72L1 and MtANR are localized in the cytosol, whereas TT10 is localized to the vacuole. Over-expression of UGT72L1 in M. truncatula hairy roots results in increased accumulation of PA-like compounds, and loss of function of UGT72L1 partially reduces epicatechin, E3'OG and extractable PA levels in M. truncatula seeds. Expression of UGT72L1 in A. thaliana leads to a massive increase in E3'OG in immature seed, but reduced levels of extractable PAs. However, when UGT72L1 was expressed in the Arabidopsis tt10 mutant, extractable PA levels increased and seed coat browning was delayed. Our results suggest that glycosylation of epicatechin is important for both PA precursor transport and assembly, but that additional redundant pathways may exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.