ArticleLab on a chip2013
Microfluidic LC device with orthogonal sample extraction for on-chip MALDI-MS detection.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- [Recent advances in microchip liquid chromatography].Se pu = Chinese journal of chromatography · 2021Article
- Chip-based ion chromatography (chip-IC) with a sensitive five-electrode conductivity detector for the simultaneous detection of multiple ions in drinking water.Microsystems & nanoengineering · 2020Article
- Achieving Stable Electrospray Ionization Mass Spectrometry Detection from Microfluidic Chips.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Microfluidic reactors for advancing the MS analysis of fast biological responses.Microsystems & nanoengineering · 2019Article
- Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor.Journal of visualized experiments : JoVE · 2016Article
- Microfluidics-to-mass spectrometry: a review of coupling methods and applications.Journal of chromatography. A · 2015Review
- Advances in and prospects of microchip liquid chromatography.Trends in analytical chemistry : TRACArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A microfluidic device that enables on-chip matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) detection for liquid chromatography (LC) separations is described. The device comprises an array of functional elements to carry out LC separations, integrates a novel microchip-MS interface to facilitate the orthogonal transposition of the microfluidic LC channel into an array of reservoirs, and enables sensitive MALDI-MS detection directly from the chip. Essentially, the device provides a snapshot MALDI-MS map of the content of the separation channel present on the chip. The detection of proteins with biomarker potential from MCF10A breast epithelial cell extracts, and detection limits in the low fmol range, are demonstrated. In addition, the design of the novel LC-MALDI-MS chip entices the promotion of a new concept for performing sample separations within the limited time-frame that accompanies the dead-volume of a separation channel.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.