Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014
Clinical value of tranexamic acid in unilateral and simultaneous bilateral TKAs under a contemporary blood-saving protocol: a randomized controlled trial.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443920 (Comparison of the Effect of Two Common Regimens of Administration of Tranexamic Acid on Hemostasis and Clinical Outcome of Patients Undergoing Total Knee Arthroplasty), which is not on this map. Cited by 33 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effect of Two Common Regimens of Administration of Tranexamic Acid on Hemostasis and Clinical Outcome of Patients Undergoing Total Knee Arthroplasty
Who cites it
33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2024Pooled it
- Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials.BioMed research international · 2021Pooled it
- Effectiveness and safety of the use of antifibrinolytic agents in total-knee arthroplasty: A meta-analysis.Medicine · 2020Pooled it
- Are perioperative interventions effective in preventing chronic pain after primary total knee replacement? A systematic review.BMJ open · 2019Pooled it
- Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials.Blood transfusion = Trasfusione del sangue · 2018Pooled it
- The effectiveness and safety of tranexamic acid in bilateral total knee arthroplasty: A meta-analysis.Medicine · 2016Pooled it
- Efficacy and Safety of Tranexamic Acid in Bilateral Total Knee Replacement: A Meta-Analysis and Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2015Pooled it
- The efficacy and safety of different does of intravenous tranexamic acid on blood loss in fresh foot and ankle fractures: a prospective, randomized controlled study.BMC musculoskeletal disorders · 2024Trial
- Use of tranexamic acid does not influence perioperative outcomes in ambulatory foot and ankle surgery-a prospective triple blinded randomized controlled trial.International orthopaedics · 2021Trial
- Comparison of Floseal® and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study.Clinics (Sao Paulo, Brazil) · 2019Trial
- Tranexamic acid in primary total knee arthroplasty without tourniquet: a randomized, controlled trial of oral versus intravenous versus topical administration.Scientific reports · 2018Trial
- After early release of tourniquet in total knee arthroplasty, should it be reinflated or kept deflated? A randomized trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Trial
- What is the Ideal Route of Administration of Tranexamic Acid in TKA? A Randomized Controlled Trial.Clinical orthopaedics and related research · 2017Trial
- Do older patients fare worse following unilateral or single stage bilateral total knee arthroplasty?Archives of orthopaedic and trauma surgery · 2023Article
- Should we use similar perioperative protocols in patients undergoing unilateral and bilateral one-stage total knee arthroplasty?World journal of orthopedics · 2022Article
- Tranexamic acid is associated with decreased transfusion, hospital length of stay, and hospital cost in simultaneous bilateral total knee arthroplasty.Bosnian journal of basic medical sciences · 2021Article
- Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.JAMA surgery · 2021Article
- Tranexamic Acid Use in Foot and Ankle Surgery.Foot & ankle orthopaedics · 2020Article
- Reply to the Letter to the Editor: Combined Intravenous and Intraarticular Tranexamic Acid Does Not Offer Additional Benefit Compared with Intraarticular Use Alone in Bilateral TKA: A Randomized Controlled Trial.Clinical orthopaedics and related research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite the documented blood-saving effects of tranexamic acid (TNA) in total knee arthroplasty (TKA), the question whether clinical values of TNA are identical in unilateral and bilateral TKAs remains unclear. This study was undertaken to determine the clinical values of TNA in unilateral and simultaneous bilateral TKAs under a contemporary blood-saving protocol in terms of efficacy (total blood loss and transfusion rate) and safety (the incidences of symptomatic deep vein thrombosis and pulmonary embolism).
methodsOne hundred and eighty unilateral and 146 bilateral TKA patients were randomized into TNA group or control group. In unilateral TKA patients, TNA (10 mg/kg) was administered intravenously 20 min before tourniquet deflation and repeated 3 h after surgery. In bilateral TKA patients, one more dose (10 mg/kg) was given before tourniquet deflation in the second TKA. A contemporary blood-saving protocol was applied to all patients. The TNA and control groups were compared separately in unilateral and bilateral TKA patients for the efficacy and safety variables.
resultsIn unilateral TKA patients, the TNA group had less total blood loss (905 vs. 1,018 mL, p = 0.018) than the control group, but there was no difference in the allogenic transfusion rate (1 vs. 7 %, n.s.). In bilateral TKA patients, the TNA group showed no differences in total blood loss (1,282 vs. 1,379 mL, n.s.), but a significant reduction in the allogenic transfusion rate (7 vs. 27 %, p = 0.002). No symptomatic deep vein thrombosis or pulmonary embolism was found in all patients.
conclusionThis study demonstrates that the use of TNA reduces total blood loss, but the effects on the transfusion rate can differ depending on the type of TKAs (unilateral vs. bilateral) and the blood-saving protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.