ReviewJournal of mammary gland biology and neoplasia2013
Ectodysplasin/NF-κB signaling in embryonic mammary gland development.
Review in Journal of mammary gland biology and neoplasia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Decoding the Collagenome in Breast Cancer: Mechanotransduction, Microenvironment, and Translational Opportunities.International journal of molecular sciences · 2026Review
- Embryonic Mammary Gland Morphogenesis.Advances in experimental medicine and biology · 2025Review
- Identification of Goat Supernumerary Teat Phenotype Using Wide-Genomic Copy Number Variants.Animals : an open access journal from MDPI · 2024Article
- Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.eLife · 2024Article
- Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.The Journal of investigative dermatology · 2023Article
- The Role of Ectodysplasin A on the Ocular Surface Homeostasis.International journal of molecular sciences · 2022Review
- Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.Integrative organismal biology (Oxford, England) · 2022Article
- Exploring regulatory network of metabolism through liver research.Diabetology international · 2021Review
- Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021Review
- No evidence for preferential X-chromosome inactivation as the main cause of divergent phenotypes in sisters with X-linked hypohidrotic ectodermal dysplasia.Orphanet journal of rare diseases · 2021Article
- Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic Mammary Gland.Journal of mammary gland biology and neoplasia · 2020Article
- Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression.Molecular biology reports · 2020Review
- Natural history of X-linked hypohidrotic ectodermal dysplasia: a 5-year follow-up study.Orphanet journal of rare diseases · 2020Article
- Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate.Biology open · 2019Article
- Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy.Journal of mammary gland biology and neoplasia · 2018Article
- Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.Nature medicine · 2017Article
- Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.Scientific reports · 2017Article
- Hypohidrotic Ectodermal Dysplasia: Breastfeeding Complications Due to Impaired Breast Development.Geburtshilfe und Frauenheilkunde · 2017Article
- Differentiation of Human Induced Pluripotent Stem Cells to Mammary-like Organoids.Stem cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ectodysplasin (Eda) signaling pathway consists of a TNF-like ligand Eda, its receptor Edar, and an adaptor protein Edaradd and its activation leads to NF-κB mediated transcription. In humans, mutations in the EDA pathway genes cause hypohidrotic ectodermal dysplasia, a disorder characterized by defective formation of hair follicles, teeth, and several exocrine glands including the breast. Embryonic mammary gland development proceeds via placode, bud, bulb and sprout stages before the onset of branching morphogenesis. Studies on mouse models have linked Eda with two aspects of embryonic mammary gland morphogenesis: placode induction and ductal growth and branching. Here we summarize the current knowledge on the role of Eda/NF-κB in mammary gland development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.