ArticleMolecular systems biology2013
Increasing population growth by asymmetric segregation of a limiting resource during cell division.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Single cell profiling framework reveals metabolic subpopulations as drivers of bioproduction heterogeneity.Nature communications · 2025Article
- The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance inCurrent clinical microbiology reports · 2023Article
- Resolving noise-control conflict by gene duplication.PLoS biology · 2019Article
- Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter.Nature communications · 2017Article
- Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness.Current biology : CB · 2016Article
- Developmental mechanisms underlying variable, invariant and plastic phenotypes.Annals of botany · 2016Review
- Article
- Loss of growth homeostasis by genetic decoupling of cell division from biomass growth: implication for size control mechanisms.Molecular systems biology · 2014Article
- A stochastic model correctly predicts changes in budding yeast cell cycle dynamics upon periodic expression of CLN2.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report that when budding yeast are transferred to low-metal environment, they adopt a proliferation pattern in which division is restricted to the subpopulation of mother cells which were born in rich conditions, before the shift. Mother cells continue to divide multiple times following the shift, generating at each division a single daughter cell, which arrests in G1. The transition to a mother-restricted proliferation pattern is characterized by asymmetric segregation of the vacuole to the mother cell and requires the transcription repressor Whi5. Notably, while deletion of WHI5 alleviates daughter cell division arrest in low-zinc conditions, it results in a lower final population size, as cell division rate becomes progressively slower. Our data suggest a new stress-response strategy, in which the dilution of a limiting cellular resource is prevented by maintaining it within a subset of dividing cells, thereby increasing population growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.