ArticleJournal of exposure science & environmental epidemiology
Uranium associations with kidney outcomes vary by urine concentration adjustment method.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Isotopic Fractionation of Natural Uranium in Mice as a Potential Biomarker of Renal Accumulation.Environmental science & technology · 2025Article
- Geographic and dietary differences of urinary uranium levels in the Strong Heart Family Study.Journal of exposure science & environmental epidemiology · 2025Article
- Uranium exposure and kidney tubule biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Environmental research · 2025Article
- Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA).Analytical methods : advancing methods and applications · 2024Article
- Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward.Environmental health perspectives · 2021Review
- Low- and moderate- levels of arsenic exposure in young adulthood and incidence of chronic kidney disease: Findings from the CARDIA Trace Element Study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- Health Effects and Environmental Justice Concerns of Exposure to Uranium in Drinking Water.Current environmental health reports · 2016Review
- Toxic environmental exposures and kidney health in children.Pediatric nephrology (Berlin, Germany) · 2016Review
- Association of arsenic with kidney function in adolescents and young adults: Results from the National Health and Nutrition Examination Survey 2009-2012.Environmental research · 2015Article
- Uranium-Toxicity and Uranium-Induced Osteosarcoma Using A New Regimen and Surgery : A First-Time Experience.Journal of clinical and diagnostic research : JCDR · 2015Article
- Urine osmolality in the US population: implications for environmental biomonitoring.Environmental research · 2015Article
- Urinary creatinine adjustment for uranium and kidney outcomes from lead workers.Journal of exposure science & environmental epidemiology · 2015Article
- Impact of urine concentration adjustment method on associations between urine metals and estimated glomerular filtration rates (eGFR) in adolescents.Environmental research · 2014Article
- Challenges for environmental epidemiology research: are biomarker concentrations altered by kidney function or urine concentration adjustment?Journal of exposure science & environmental epidemiologyReview
- Urinary trace element concentrations in environmental settings: is there a value for systematic creatinine adjustment or do we introduce a bias?Journal of exposure science & environmental epidemiologyArticle
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13 authors at 5 institutions in 2 countries.
Funding
Abstract
Uranium is a ubiquitous metal that is nephrotoxic at high doses. Few epidemiologic studies have examined the kidney filtration impact of chronic environmental exposure. In 684 lead workers environmentally exposed to uranium, multiple linear regression was used to examine associations of uranium measured in a 4-h urine collection with measured creatinine clearance, serum creatinine- and cystatin-C-based estimated glomerular filtration rates, and N-acetyl-β-D-glucosaminidase (NAG). Three methods were utilized, in separate models, to adjust uranium levels for urine concentration--μg uranium/g creatinine; μg uranium/l and urine creatinine as separate covariates; and μg uranium/4 h. Median urine uranium levels were 0.07 μg/g creatinine and 0.02 μg/4 h and were highly correlated (rs=0.95). After adjustment, higher ln-urine uranium was associated with lower measured creatinine clearance and higher NAG in models that used urine creatinine to adjust for urine concentration but not in models that used total uranium excreted (μg/4 h). These results suggest that, in some instances, associations between urine toxicants and kidney outcomes may be statistical, due to the use of urine creatinine in both exposure and outcome metrics, rather than nephrotoxic. These findings support consideration of non-creatinine-based methods of adjustment for urine concentration in nephrotoxicant research.
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