ArticleScientific reports2013
The distribution of haemoglobin C and its prevalence in newborns in Africa.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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Who cites it
63 citing papers in PubMed, 130 citations in OpenAlex.
- High-throughput genotyping assays for identification of glycophorin B deletion variants in population studies.Experimental biology and medicine (Maywood, N.J.) · 2021Trial
- Article
- Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana.Malaria journal · 2026Article
- The Epidemiology of Sickle Cell Disease in Sub-Saharan Africa: Current Knowledge and Gaps to be Filled.American journal of hematology · 2026Review
- Molecular diagnosis of HTLV-1 and HCV infection in polytransfused sickle cell disease in Kinshas: case of CMMASS.BMC infectious diseases · 2026Article
- Hemoglobin C Disease With Splenomegaly and With Factor II Mutation Gene Thrombophilia: A Case Report.Cureus · 2025Article
- Screening for sickle cell anemia in two populations of eastern Gabon using alkaline electrophoresis and hemoglobin level combined with leukocyte count.International journal of hematology · 2025Article
- Sickle cell retinopathy among Ghanaian high school students: a school-based screening.BMJ global health · 2024Article
- Epidemiologic profile of hemoglobinopathies in Benin.Hematology, transfusion and cell therapy · 2024Article
- Ten years of a neonatal screening program for hemoglobinopathies in Friuli-Venezia Giulia: first regional experience in Italy.Blood transfusion = Trasfusione del sangue · 2024Article
- Prevalence and Regional Distribution of Beta-Hemoglobin Variants in Saudi Arabia: Insights from the National Premarital Screening Program".Journal of epidemiology and global health · 2024Article
- Regional Prevalence of Hemoglobin C Across Saudi Arabia: An Epidemiological Survey.Journal of epidemiology and global health · 2024Article
- Molecular epidemiology and hematological profiles of hemoglobin variants in southern Thailand.Scientific reports · 2024Article
- Hemoglobin C Disorder in Anemic Patients Referred to the National Center for Thalassemia and Genetic Counseling in Damascus.International journal of hematology-oncology and stem cell research · 2024Article
- Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age.BMC public health · 2024Article
- A novel locus inFrontiers in genetics · 2024Article
- Article
- [Hemoglobin C Variant Affecting Glycated Hemoglobin Test Results: A Rare Case Report].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Ancestry, diversity, and genetics of health-related traits in African-derived communities (quilombos) from Brazil.Functional & integrative genomics · 2023Review
- Oral microbiota analyses of Saudi sickle cell anemics with dental caries.International dental journal · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Haemoglobin C (HbC) is one of the commonest structural haemoglobin variants in human populations. Although HbC causes mild clinical complications, its diagnosis and genetic counselling are important to prevent inheritance with other haemoglobinopathies. Little is known about its contemporary distribution and the number of newborns affected. We assembled a global database of population surveys. We then used a Bayesian geostatistical model to create maps of HbC frequency across Africa and paired our predictions with high-resolution demographics to calculate heterozygous (AC) and homozygous (CC) newborn estimates and their associated uncertainty. Data were too sparse outside Africa for this methodology to be applied. The highest frequencies were found in West Africa but HbC was commonly found in other parts of the continent. The expected annual numbers of AC and CC newborns in Africa were 672,117 (interquartile range (IQR): 642,116-705,163) and 28,703 (IQR: 26,027-31,958), respectively. These numbers are about two times previous estimates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.