ReviewCurrent atherosclerosis reports2013
Genetics of HDL-C: a causal link to atherosclerosis?
Review in Current atherosclerosis reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- Prognostic value of preoperative inflammatory cell-to-HDL cholesterol ratios in patients with non-metastatic clear cell renal cell carcinoma.Frontiers in oncology · 2026Article
- Association between circulatory immune cell to high-density lipoprotein cholesterol ratios and testosterone level in adult men: findings from NHANES 2011-2016.BMC endocrine disorders · 2025Article
- Two Sides of Triglycerides in Atherogenesis: An Essential Contributor.Clinical Medicine Insights. Cardiology · 2025Review
- Lutein and Zeaxanthin Enhance, Whereas Oxidation, Fructosylation, and Low pH Damage High-Density Lipoprotein Biological Functionality.Antioxidants (Basel, Switzerland) · 2024Article
- Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes.International journal of molecular sciences · 2023Review
- Effects of ambient particulate exposure on blood lipid levels in hypertension inpatients.Frontiers in public health · 2023Article
- Dynamic Resistance Exercise Alters Blood ApoA-I Levels, Inflammatory Markers, and Metabolic Syndrome Markers in Elderly Women.Healthcare (Basel, Switzerland) · 2022Article
- Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients.Scientific reports · 2018Article
- High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease.Drugs in context · 2018Review
- HDL Cholesterol Efflux Does Not Predict Cardiovascular Risk in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2017Article
- Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B.International journal of medical sciences · 2017Article
- Article
- Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein.Journal of lipid research · 2015Article
- Reconstituted high-density lipoprotein therapies: a cause for optimism.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Increased burden of cardiovascular disease in carriers of APOL1 genetic variants.Circulation research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal relationship between HDL-C and atherosclerosis. HDL-C levels have been shown to be highly heritable, and the combination of HDL-C-associated SNPs in recent large-scale genome-wide association studies (GWAS) only explains a small proportion of this heritability. As a large part of our current understanding of HDL metabolism comes from genetic studies, further insights in this research field may aid us in elucidating HDL functionality in relation to CVD risk. In this review we focus on the question of whether genetically defined HDL-C levels are associated with risk of atherosclerosis. We also discuss the latest insights for HDL-C-associated genes and recent GWAS data.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.