Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- [Biomolecules · 2025Article
- The role of striatal dopamine DPsychopharmacology · 2018Article
- Test-retest measurements of dopamine DEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Variability in paralimbic dopamine signaling correlates with subjective responses to d-amphetamine.Neuropharmacology · 2016Article
- Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease.Brain : a journal of neurology · 2016Article
- Application of Diffusion Tensor Imaging Parameters to Detect Change in Longitudinal Studies in Cerebral Small Vessel Disease.PloS one · 2016Article
- Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Characterising the grey matter correlates of leukoaraiosis in cerebral small vessel disease.NeuroImage. Clinical · 2015Article
- Imaging dopaminergic dysfunction as a surrogate marker of neuropathology in a small-animal model of HIV.Molecular imaging · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
[(18)F]fallypride is a high-affinity dopamine D2/3 receptor tracer with the ability to reliably quantify D2/3 receptor sites in both striatal and corticolimbic regions. The translational potential of [(18)F]fallypride imaging is, however, limited by the lengthy scanning sessions (60-80 minutes duration over a total of 3-4 hours) required by current protocols. The aims of our study were to adapt [(18)F]fallypride imaging for use in clinical populations with neurological and neuropsychiatric disorders, by reducing the duration of individual scanning sessions; and to establish the reproducibility and reliability of our adapted protocol in healthy older people. Eight participants (five male and three female; mean age=75.87±4.39 years) were scanned twice, 4-6 weeks apart. [(18)F]fallypride binding potential was determined from image data collected during three sampling times: 0-30; 60-90; and 210-240 minutes post injection. High reproducibility and reliability (test-retest variability <8%; intraclass correlation coefficient >0.8) were observed in all but the prefrontal regions, and remained so when sampling times were reduced to 20 minutes (0-20; 70-90; 220-240 minutes). The adapted protocol is feasible for use across neuropsychiatric disorders in which dopamine has been implicated and is sufficiently sensitive to detect within-subject changes between 2.7% and 5.5% in striatal and limbic regions.
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