ArticleMolecular genetics and genomics : MGG2013
Increased copy number at the HvFT1 locus is associated with accelerated flowering time in barley.
Article in Molecular genetics and genomics : MGG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Multi-omics revolution to promote plant breeding efficiency.Frontiers in plant science · 2022Pooled it
- Analysis of the synergistic effect between CiFTIP1 and CiFT in flowering regulation of citrus.Planta · 2026Article
- Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber.Nature genetics · 2026Article
- A telomere-to-telomere gap-free genome of the new cultivar 'Zhongtian No. 5', combined with pan-genome analysis, aids in exploration and genetic enhancement of red clover (Horticulture research · 2026Article
- How Structural Variations Influence Crop Improvement.International journal of molecular sciences · 2025Review
- Article
- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- A comprehensive map of DNA-segment copy number variation in 491 genomes of common wheat uncovers genes associated with multiple agronomic traits.Plant communications · 2025Article
- Genome-wide identification of copy number variation in diverse black pepper accessions.Planta · 2025Article
- Genome-wide association study and genome prediction of tallness trait in spinach phenotyping.Frontiers in plant science · 2025Article
- Copy number variation introduced by a massive mobile element facilitates global thermal adaptation in a fungal wheat pathogen.Nature communications · 2024Article
- Analysis of Genome Structure and Its Variations in Potato Cultivars Grown in Russia.International journal of molecular sciences · 2023Article
- Article
- The genetic architecture of flowering time changes in pea from wild to crop.Journal of experimental botany · 2022Article
- Genetic analysis of early phenology in lentil identifies distinct loci controlling component traits.Journal of experimental botany · 2022Article
- MiR172-APETALA2-like genes integrate vernalization and plant age to control flowering time in wheat.PLoS genetics · 2022Article
- Contemplation on wheat vernalization.Frontiers in plant science · 2022Review
- Hybrids Provide More Options for Fine-Tuning Flowering Time Responses of Winter Barley.Frontiers in plant science · 2022Article
- The Breeding of Winter-Hardy Malting Barley.Plants (Basel, Switzerland) · 2021Review
- Major flowering time genes of barley: allelic diversity, effects, and comparison with wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
A precise regulation of flowering time is critical for plant reproductive success, and therefore, a better understanding of the natural variation in genes regulating the initiation of the reproductive phase is required to develop well-adapted varieties. In both monocot and dicot species, the FLOWERING LOCUS T (FT) is a central integrator of seasonal signals perceived by the leaves. The encoded mobile protein (florigen) is transmitted to the apical meristem where it induces flowering. The FT homolog in barley (Hordeum vulgare L.), designated HvFT1, was shown to correspond to the vernalization locus VRN-H3, and natural alleles for spring and winter growth habit were identified. In this study, we demonstrate that the HvFT1 allele present in the barley genetic stock (BGS213) associated with a dominant spring growth habit carries at least four identical copies of HvFT1, whereas most barley varieties have a single copy. Increased copy number is associated with earlier transcriptional up-regulation of HvFT1 and a spring growth habit. This allele is epistatic to winter alleles for VRN-H1 and VRN-H2. Among accessions with one HvFT1 copy, haplotype differences in the HvFT1 promoter and first intron are also associated with differences in flowering time, which are modulated by genetic background. These different HvFT1 alleles can be used to develop barley varieties adapted to different or changing environments. Our results, together with studies of other wheat and barley flowering genes, show that copy number variation plays an important role in the regulation of developmental processes in the temperate cereals.
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