ArticleEnvironmental health perspectives2013
Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters.Obesity (Silver Spring, Md.) · 2025Article
- Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study.Environment international · 2025Article
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- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects.International journal of environmental research and public health · 2021Review
- Cardiotoxicity of some pesticides and their amelioration.Environmental science and pollution research international · 2021Review
- Environmental Contaminant Body Burdens and the Relationship with Blood Pressure Measures Among Indigenous Adults.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age.International journal of obesity (2005) · 2020Article
- In utero DDT exposure and breast density in early menopause by maternal history of breast cancer.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.Frontiers in public health · 2020Review
- Developmental Expression of the Cytosolic Sulfotransferases in Human Liver.Drug metabolism and disposition: the biological fate of chemicals · 2019Article
- Early-life exposure to endocrine disrupting chemicals associates with childhood obesity.Annals of pediatric endocrinology & metabolism · 2018Article
- Persistent Organochlorine Pollutants in Plasma, Blood Pressure, and Hypertension in a Longitudinal Study.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Exposure to DDT and hypertensive disorders of pregnancy among South African women from an indoor residual spraying region: The VHEMBE study.Environmental research · 2018Article
- Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women.American journal of epidemiology · 2018Article
- The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity.Environmental research · 2018Article
- Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks.Annals of the New York Academy of Sciences · 2017Review
- Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice.Environmental health perspectives · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundElevated levels of the pesticide DDT (dichlorodiphenyltrichloroethane) have been positively associated with blood pressure and hypertension in studies among adults. Accumulating epidemiologic and toxicologic evidence suggests that hypertension during adulthood may also be affected by earlier life and possibly the prenatal environment.
objectivesWe assessed whether prenatal exposure to the pesticide DDT increases risk of adult hypertension.
methodsWe examined concentrations of DDT (p,p´- and o,p´-) and its metabolite p,p´-DDE (dichlorodiphenyldichloroethylene) in prenatal serum samples from a subset of women (n = 527) who had participated in the prospective Child Health and Development Studies birth cohort in the San Francisco Bay area while they were pregnant between 1959 and 1967. We surveyed daughters 39-47 years of age by telephone interview from 2005 to 2008 to obtain information on self-reported physician-diagnosed hypertension and use of hypertensive medication. We used multivariable regression analysis of time to hypertension based on the Cox proportional hazards model to estimate relative rates for the association between prenatal DDT exposures and hypertension treated with medication in adulthood, with adjustment for potential confounding by maternal, early-life, and adult exposures.
resultsPrenatal p,p´-DDT exposure was associated with hypertension [adjusted hazard ratio (aHR) = 3.6; 95% CI: 1.8, 7.2 and aHR = 2.5; 95% CI: 1.2, 5.3 for middle and high tertiles of p,p´-DDT relative to the lowest tertile, respectively]. These associations between p,p´-DDT and hypertension were robust to adjustment for independent hypertension risk factors as well as sensitivity analyses.
conclusionsThese findings suggest that the association between DDT exposure and hypertension may have its origins early in development.
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