ArticleScientific reports2013
Turning oscillations into opportunities: lessons from a bacterial decision gate.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Changes in Spo0A~P pulsing frequency control biofilm matrix deactivation.PLoS computational biology · 2025Article
- Agency as an Inherent Property of Living Organisms.Biological theory · 2024Review
- Large-Scale Identification of Known and Novel RRNPP Quorum-Sensing Systems by RRNPP_Detector Captures Novel Features of Bacterial, Plasmidic, and Viral Coevolution.Molecular biology and evolution · 2023Article
- Theoretical study of the impact of adaptation on cell-fate heterogeneity and fractional killing.Scientific reports · 2020Article
- RNA Regulatory Networks as a Control of Stochasticity in Biological Systems.Frontiers in genetics · 2019Review
- Article
- Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways.Nature communications · 2018Article
- Dynamic Modeling ofFrontiers in microbiology · 2018Article
- Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation.PLoS computational biology · 2017Article
- Periodic, Quasi-periodic and Chaotic Dynamics in Simple Gene Elements with Time Delays.Scientific reports · 2016Article
- Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System.PLoS computational biology · 2016Article
- The relationship between stochastic and deterministic quasi-steady state approximations.BMC systems biology · 2015Article
- Modeling of the ComRS Signaling Pathway Reveals the Limiting Factors Controlling Competence in Streptococcus thermophilus.Frontiers in microbiology · 2015Article
- The physics of bacterial decision making.Frontiers in cellular and infection microbiology · 2014Review
- Noise in biology.Reports on progress in physics. Physical Society (Great Britain) · 2014Review
- MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities - each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.