ArticleHeredity2013
Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Inference of selective forces on house mouse genomes during secondary contact in East Asia.Genome research · 2024Article
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- The Evolutionary History of Drosophila simulans Y Chromosomes Reveals Molecular Signatures of Resistance to Sex Ratio Meiotic Drive.Molecular biology and evolution · 2023Article
- Article
- Do Ty3/Gypsy Transposable Elements Play Preferential Roles in Sex Chromosome Differentiation?Life (Basel, Switzerland) · 2022Review
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- Article
- Adaptive co-evolution of mitochondria and the Y-chromosome: A resolution to conflict between evolutionary opponents.Ecology and evolution · 2021Article
- Evolution of genome structure in theGenome research · 2021Article
- Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution.Progress in molecular and subcellular biology · 2021Article
- Article
- Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019Article
- An assessment of the immune costs associated with meiotic drive elements inProceedings. Biological sciences · 2019Article
- Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues.Proceedings. Biological sciences · 2017Article
- Review
- Article
- Y-linked variation for autosomal immune gene regulation has the potential to shape sexually dimorphic immunity.Proceedings. Biological sciences · 2015Article
- Article
- Sex chromosome drive.Cold Spring Harbor perspectives in biology · 2014Review
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4 authors.
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Abstract
X-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked modifiers that restore a normal sex ratio might be abundant and favored when a X-linked distorter is present. Here we investigated natural variation of Y-linked suppressors of sex-ratio in the Winters systems and the ability of these chromosomes to modulate gene expression in Drosophila simulans. Seventy-eight Y chromosomes of worldwide origin were assayed for their resistance to the X-linked sex-ratio distorter gene Dox. Y chromosome diversity caused males to sire ∼63% to ∼98% female progeny. Genome-wide gene expression analysis revealed hundreds of genes differentially expressed between isogenic males with sensitive (high sex ratio) and resistant (low sex ratio) Y chromosomes from the same population. Although the expression of about 75% of all testis-specific genes remained unchanged across Y chromosomes, a subset of post-meiotic genes was upregulated by resistant Y chromosomes. Conversely, a set of accessory gland-specific genes and mitochondrial genes were downregulated in males with resistant Y chromosomes. The D. simulans Y chromosome also modulated gene expression in XXY females in which the Y-linked protein-coding genes are not transcribed. The data suggest that the Y chromosome might exert its regulatory functions through epigenetic mechanisms that do not require the expression of protein-coding genes. The gene network that modulates sex ratio distortion by the Y chromosome is poorly understood, other than that it might include interactions with mitochondria and enriched for genes expressed in post-meiotic stages of spermatogenesis.
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